Dynamical aspects of the total QSSA in Enzyme Kinetics

arXiv1702.05351MaRDI QIDQ6283300FDOQ6283300

Authors: Alberto Bersani, Enrico Bersani, Alessandro Borri, Pierluigi Vellucci 

Publication date: 17 February 2017

Abstract: In this paper we prove that the well-known quasi-steady state approximations, commonly used in enzyme kinetics, which can be interpreted as the reduced system of a differential system depending on a perturbative parameter, according to Tihonov theory, are asymptotically equivalent to the center manifold of the system. This allows to give a mathematical foundation for the application of a mechanistic method to determine the center manifold of (at this moment, still simple) enzyme reactions.

Mathematics Subject Classification ID

Transformation and reduction of ordinary differential equations and systems, normal forms (34C20) Invariant manifolds for ordinary differential equations (34C45) Stability of solutions to ordinary differential equations (34D20) Invariant manifold theory for dynamical systems (37D10) General biology and biomathematics (92B05) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Asymptotic expansions of solutions to ordinary differential equations (34E05) Perturbations, asymptotics of solutions to ordinary differential equations (34E10) Singular perturbations of ordinary differential equations (34D15)

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