Duality Between Relaxation and First Passage in Reversible Markov Dynamics: Rugged Energy Landscapes Disentangled

DOI10.1088/1367-2630/AAF038arXiv1802.10046WikidataQ128960714 ScholiaQ128960714MaRDI QIDQ6298317FDOQ6298317

Authors: David Hartich, Aljaž Godec 

Publication date: 27 February 2018

Abstract: Relaxation and first passage processes are the pillars of kinetics in condensed matter, polymeric and single-molecule systems. Yet, an explicit connection between relaxation and first passage time-scales so far remained elusive. Here we prove a duality between them in the form of an interlacing of spectra. In the basic form the duality holds for reversible Markov processes to effectively one-dimensional targets. The exploration of a triple-well potential is analyzed to demonstrate how the duality allows for an intuitive understanding of first passage trajectories in terms of relaxational eigenmodes. More generally, we provide a comprehensive explanation of the full statistics of reactive trajectories in rugged potentials, incl. the so-called `few-encounter limit'. Our results are required for explaining quantitatively the occurrence of diseases triggered by protein misfolding.

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