Computational approaches for parametric imaging of dynamic PET data
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Publication:6324372
arXiv1908.11139MaRDI QIDQ6324372FDOQ6324372
Authors: Serena Crisci, Michele Piana, V. Ruggiero, Mara Scussolini 
Publication date: 29 August 2019
Abstract: Parametric imaging of nuclear medicine data exploits dynamic functional images in order to reconstruct maps of kinetic parameters related to the metabolism of a specific tracer injected in the biological tissue. From a computational viewpoint, the realization of parametric images requires the pixel-wise numerical solution of compartmental inverse problems that are typically ill-posed and nonlinear. In the present paper we introduce a fast numerical optimization scheme for parametric imaging relying on a regularized version of the standard affine-scaling Trust Region method. The validation of this approach is realized in a simulation framework for brain imaging and comparison of performances is made with respect to a regularized Gauss-Newton scheme and a standard nonlinear least-squares algorithm.
Numerical mathematical programming methods (65K05) Biomedical imaging and signal processing (92C55) Inverse problems involving ordinary differential equations (34A55) Numerical solutions of ill-posed problems in abstract spaces; regularization (65J20)
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