Time-adaptive optimization in a parameter identification problem of HIV infection

arXiv1912.01112MaRDI QIDQ6330299FDOQ6330299

Publication date: 29 November 2019

Abstract: The paper considers a time-adaptive method for determination of drug efficacy in a parameter identification problem (PIP) for system of ordinary differential equations (ODE) which describe dynamics of the primary HIV infection. Optimization approach to solve this problem is presented and a posteriori error estimates in the Tikhonov functional and Lagrangian are formulated. Based on these estimates a time adaptive algorithm is formulated and numerically tested for different scenarios of noisy observations of virus population function. Numerical results show significant improvement of reconstruction of drug efficacy parameter when using time adaptive mesh refinement compared to usual gradient method applied on a uniform time mesh.

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