Tractable nonlinear memory functions as a tool to capture and explain dynamical behaviours

DOI10.1103/PHYSREVRESEARCH.2.043069arXiv2005.04751MaRDI QIDQ6340403FDOQ6340403

Edgar Herrera-Delgado, Peter Sollich, James Briscoe

Publication date: 10 May 2020

Abstract: Mathematical approaches from dynamical systems theory are used in a range of fields. This includes biology where they are used to describe processes such as protein-protein interaction and gene regulatory networks. As such networks increase in size and complexity, detailed dynamical models become cumbersome, making them difficult to explore and decipher. This necessitates the application of simplifying and coarse graining techniques in order to derive explanatory insight. Here we demonstrate that Zwanzig-Mori projection methods can be used to arbitrarily reduce the dimensionality of dynamical networks while retaining their dynamical properties. We show that a systematic expansion around the quasi-steady state approximation allows an explicit solution for memory functions without prior knowledge of the dynamics. The approach not only preserves the same steady states but also replicates the transients of the original system. The method also correctly predicts the dynamics of multistable systems as well as networks producing sustained and damped oscillations. Applying the approach to a gene regulatory network from the vertebrate neural tube, a well characterised developmental transcriptional network, identifies features of the regulatory network responsible dfor its characteristic transient behaviour. Taken together, our analysis shows that this method is broadly applicable to multistable dynamical systems and offers a powerful and efficient approach for understanding their behaviour.

Mathematics Subject Classification ID

Dynamical systems in biology (37N25) Systems biology, networks (92C42) Developmental biology, pattern formation (92C15) Approximation methods and numerical treatment of dynamical systems (37M99)

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