Modeling and simulation of nuclear architecture reorganization process using a phase field approach

DOI10.1016/J.JCP.2021.110808MaRDI QIDQ6363073arXivFDO

Authors Qing Cheng, Pourya Delafrouz, J. Liang, Chun Liu, Jie Shen

Publication date 11 March 2021

Published in arXiv

Full work available at URL https://doi.org/10.1016/J.JCP.2021.110808

Mathematics Subject Classification ID

Parabolic equations and parabolic systems (35Kxx) Numerical methods for partial differential equations, initial value and time-dependent initial-boundary value problems (65Mxx) Physiological, cellular and medical topics (92Cxx)

arXiv classification

cs.NAmath.NA

Abstract: We develop a special phase field/diffusive interface method to model the nuclear architecture reorganization process. In particular, we use a Lagrange multiplier approach in the phase field model to preserve the specific physical and geometrical constraints for the biological events. We develop several efficient and robust linear and weakly nonlinear schemes for this new model. To validate the model and numerical methods, we present ample numerical simulations which in particular reproduce several processes of nuclear architecture reorganization from the experiment literature.

Recommendations

• Computational Methods in Systems Biology
• A computational model of nuclear self-organisation in syncytial embryos
• Nucleus Modelling and Segmentation in Cell Clusters
• Publication:4860370
• A new application of the phase-field method for understanding the mechanisms of nuclear architecture reorganization
• Mathematical modeling accurately predicts the dynamics and scaling of nuclear growth in discrete cytoplasmic volumes
• Modeling and manipulating cell complexes in two, three and higher dimensions
• scientific article; zbMATH DE number 2043779
• Whole-cell modeling framework in which biochemical dynamics impact aspects of cellular geometry

This page was built for publication: Modeling and simulation of nuclear architecture reorganization process using a phase field approach

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q6363073)