Bifurcation analysis for a free boundary problem modeling tumor growth

DOI10.1007/S00013-011-0276-8MaRDI QIDQ636747zbMATH OpenOpenAlexFDO

Authors Anca-Vocihita Matioc, Joachim Escher

Publication date 30 August 2011

Published in Archiv der Mathematik (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1003.1216

zbMATH Keywords

bifurcation from simple eigenvaluesinfinitely many bifurcation branchesnontrivial stationary solutionssteady-statetumor growth

Mathematics Subject Classification ID

Bifurcations in context of PDEs (35B32) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Free boundary problems for PDEs (35R35) Medical applications (general) (92C50)

Abstract: In this paper we deal with a free boundary problem modeling the growth of nonnecrotic tumors.The tumor is treated as an incompressible fluid, the tissue elasticity is neglected and no chemical inhibitor species are present. We re-express the mathematical model as an operator equation and by using a bifurcation argument we prove that there exist stationary solutions of the problem which are not radially symmetric.

Review text

This paper deals with a free boundary problem modeling the growth of nonnecrotic tumors. The paper under review is concerned with the non-symmetric setting, which corresponds to the case where the tumor domain is arbitrary, and looks for nontrivial steady-states of the model. One of the main results in this paper establishes that if the rate of mitosis relative to the relaxation mechanism is large, then the circular equilibrium is unstable, which also suggests existence of nontrivial stationary solutions. When studying the set of equilibria, the authors deal with a free boundary problem which is reduced to an operator equation between certain subspaces of the small Hölder spaces over the unit circle. Next, by means of the theorem on bifurcations from simple eigenvalues, the authors obtain infinitely many bifurcation branches consisting only of stationary solutions of the considered model.

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Cited in

(39)

• Bifurcations for a multidimensional free boundary problem modeling the growth of tumor cord
• On eigenvalues of the linearization of a free boundary problem modeling two-phase tumor growth
• Stationary solutions of a free boundary problem modeling growth of angiogenesis tumor with inhibitor
• Bifurcation for a free boundary problem modeling tumor growth with ECM and MDE interactions
• Bifurcation from stability to instability for a free boundary tumor model with angiogenesis
• The existence and linear stability of periodic solution for a free boundary problem modeling tumor growth with a periodic supply of external nutrients
• Stationary solutions of a free boundary problem modeling the growth of vascular tumors with a necrotic core
• Symmetry-breaking bifurcations for free boundary problems modeling tumor growth
• A three-dimensional angiogenesis model with time-delay
• Bifurcation, multistability in the dynamics of tumor growth and electronic simulations by the use of Pspice
• Bifurcation analysis for a free-boundary tumor model with angiogenesis and inhibitor
• Bifurcation analysis of a tumor-model free boundary problem with a nonlinear boundary condition
• Analysis of a nonlinear necrotic tumor model with two free boundaries
• Stability of solutions to a free boundary problem for tumor growth
• Radially symmetric growth of nonnecrotic tumors
• Bifurcation for a free-boundary tumor model with extracellular matrix and matrix degrading enzymes
• Bifurcation for a free boundary problem modeling the growth of tumors with a drug induced nonlinear proliferation rate
• Bifurcation solutions of a free boundary problem modeling tumor growth with angiogenesis
• Bifurcation for a free boundary problem modeling the growth of necrotic multilayered tumors
• On the justification of the quasistationary approximation of several parabolic moving boundary problems. Part I
• Stationary solutions of a free boundary problem modeling the growth of tumors with Gibbs-Thomson relation
• Bifurcation of equilibrium forms of a gas column rotating with constant speed around its axis of symmetry
• Bifurcation analysis of a free boundary model of vascular tumor growth with a necrotic core and chemotaxis
• Symmetry-breaking bifurcation of analytic solutions to free boundary problems: An application to a model of tumor growth
• Bifurcation analysis of a free boundary problem modelling tumour growth under the action of inhibitors
• On the multiplicity of solutions of a simplified tumor growth model with a free boundary
• Cell cycle control and bifurcation for a free boundary problem modeling tissue growth
• A three-dimensional steady-state tumor system
• ON THE EXISTENCE OF SPATIALLY PATTERNED DORMANT MALIGNANCIES IN A MODEL FOR THE GROWTH OF NON-NECROTIC VASCULAR TUMORS
• Local analysis of a two phase free boundary problem concerning mean curvature
• Bifurcation for a free-boundary tumor model with angiogenesis
• Bifurcation for a free boundary problem modeling the growth of multilayer tumors with ECM and MDE interactions
• Bifurcation Analysis in a Cancer Growth Model
• Bifurcation analysis of amathematical model for the growth of solid tumors in the presence of external inhibitors
• Bifurcation for a Free Boundary Problem Modeling Tumor Growth by Stokes Equation
• Bifurcation Analysis of an Elliptic Free Boundary Problem Modelling the Growth of Avascular Tumors
• Bifurcation analysis of a free boundary problem modeling multilayered tumor growth with time delay
• Symmetry breaking solutions for a two-phase overdetermined problem of Serrin-type
• Subcritical bifurcation of free elastic shell of biological cluster

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