Decision Programming for optimizing the Finnish Colorectal Cancer Screening Program

arXiv2206.13830MaRDI QIDQ6403363FDOQ6403363

Authors: Lauri Neuvonen, Mary Dillon, Eeva Vilkkumaa, Ahti Salo, Maija Jäntti, Sirpa Heinävaara 

Publication date: 28 June 2022

Abstract: In Finland colorectal cancer (CRC) incidence rates have steadily increased over the last decades and as of 2017, CRC is the sixth most common cause of death. CRC is a crucial concern for the public health of Finland. We optimize the faecal immunochemical test (FIT) cut-off level for specified target populations with regard to minimization of cancer prevalence with Decision Programming, which is a novel approach to solving discrete multi-stage decision problems under uncertainty. The results present optimal cut-off levels for Finnish target groups with different colonoscopy capacity constraints. Finally, the estimated resulting cancer prevalence, the amount of required colonoscopies and third-party payer costs resulting from found strategies to the newly implemented Finnish CRC Screening Programme, which have not previously been published, are presented.

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