Assessment of synchrony in multiple neural spike trains using loglinear point process models

DOI10.1214/10-AOAS429zbMATH Open1223.62159arXiv1107.5872OpenAlexW1979227515WikidataQ35153160 ScholiaQ35153160MaRDI QIDQ641077FDOQ641077

Authors: Robert E. Kass, Ryan C. Kelly, Wei-Liem Loh 

Publication date: 21 October 2011

Published in: The Annals of Applied Statistics (Search for Journal in Brave)

Abstract: Neural spike trains, which are sequences of very brief jumps in voltage across the cell membrane, were one of the motivating applications for the development of point process methodology. Early work required the assumption of stationarity, but contemporary experiments often use time-varying stimuli and produce time-varying neural responses. More recently, many statistical methods have been developed for nonstationary neural point process data. There has also been much interest in identifying synchrony, meaning events across two or more neurons that are nearly simultaneous at the time scale of the recordings. A natural statistical approach is to discretize time, using short time bins, and to introduce loglinear models for dependency among neurons, but previous use of loglinear modeling technology has assumed stationarity. We introduce a succinct yet powerful class of time-varying loglinear models by (a) allowing individual-neuron effects (main effects) to involve time-varying intensities; (b) also allowing the individual-neuron effects to involve autocovariation effects (history effects) due to past spiking, (c) assuming excess synchrony effects (interaction effects) do not depend on history, and (d) assuming all effects vary smoothly across time.

Full work available at URL: https://arxiv.org/abs/1107.5872

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zbMATH Keywords

spike traindiscrete-time approximationloglinear modelmarked processnonstationary point processsimultaneous eventssynchrony detection

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Point processes (e.g., Poisson, Cox, Hawkes processes) (60G55) Generalized linear models (logistic models) (62J12) Neural biology (92C20)

Cites Work

• The time-rescaling theorem and its application to neural spike train data analysis
• Maximum likelihood analysis of spike trains of interacting nerve cells
• An introduction to the theory of point processes
• Unitary events in multiple single-neuron spiking activity: II. Nonstationary data
• Unitary events in multiple single-neuron spiking activity: I. Detection and significance
• Statistical models of spike trains
• Sharp estimates for finite element approximations to elliptic problems with Neumann boundary data of low regularity

Cited In (19)

• Cross nearest-spike interval based method to measure synchrony dynamics
• A test for independence between a point process and an analogue signal
• Distributed synchrony
• Detection of mutual determinism between a pair of spike trains
• Spatiotemporal conditional inference and hypothesis tests for neural ensemble spiking precision
• An \(L_1\)-regularized logistic model for detecting short-term neuronal interactions
• Functional synchrony for point processes
• Surrogate data methods based on a shuffling of the trials for synchrony detection: the centering issue
• Title not available (Why is that?)
• Towards a mathematical definition of functional connectivity
• A conversation with Robert E. Kass
• Methods for identification of spike patterns in massively parallel spike trains
• Point-Process Principal Components Analysis via Geometric Optimization
• Likelihood methods for point processes with refractoriness
• An overview of modeling techniques for hybrid brain data
• Messages of Oscillatory Correlograms: A Spike Train Model
• Linear-nonlinear-time-warp-Poisson models of neural activity
• From univariate to multivariate coupling between continuous signals and point processes: a mathematical framework
• Nonlinear Dynamics of Point Process Systems and Data

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