Accounting for spot matching uncertainty in the analysis of proteomics data from two-dimensional gel electrophoresis

DOI10.1007/S13571-011-0016-XMaRDI QIDQ641803zbMATH OpenOpenAlexWikidataFDO

Authors Volodymyr Melnykov, Ranjan Maitra, Dan Nettleton

Publication date 25 October 2011

Published in Sankhyā. Series B (Search for Journal in Brave)

Full work available at URL https://lib.dr.iastate.edu/cgi/viewcontent.cgi?article=1074&context=stat_las_pubs

zbMATH Keywords

Markov chain Monte CarloROC curvesEM algorithmobserved information matrixGaussian mixture modelconditional point process simulationisoelectric pointsmolecular weights

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Numerical analysis or methods applied to Markov chains (65C40) Biochemistry, molecular biology (92C40) Probabilistic models, generic numerical methods in probability and statistics (65C20) Biophysics (92C05)

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Cites work

• scientific article; zbMATH DE number 3768770 (Why is no real title available?)
• scientific article; zbMATH DE number 3567782 (Why is no real title available?)
• A stochastic approximation type EM algorithm for the mixture problem
• An automated (Markov chain) Monte Carlo EM algorithm
• Bayesian alignment using hierarchical models, with applications in protein bioinformatics
• Convergence of a stochastic approximation version of the EM algorithm
• Finite mixture models
• Maximizing Generalized Linear Mixed Model Likelihoods With an Automated Monte Carlo EM Algorithm
• Nearest-Neighbour Markov Point Processes and Random Sets
• Numerical Issues in Statistical Computing for the Social Scientist
• The EM Algorithm and Extensions, 2E

Cited in

(5)

• A likelihood-based approach to defining statistical significance in proteomic analysis where missing data cannot be disregarded
• Finite mixture models and model-based clustering
• Analysis of dynamic protein expression data
• A population-size model for protein spot detection in proteomic studies
• Challenges in model-based clustering

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Uses Software

• Pinnacle

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