Accounting for spot matching uncertainty in the analysis of proteomics data from two-dimensional gel electrophoresis

DOI10.1007/S13571-011-0016-XzbMATH Open1230.92017OpenAlexW2019121759WikidataQ57709241 ScholiaQ57709241MaRDI QIDQ641803FDOQ641803

Authors: Volodymyr Melnykov, Ranjan Maitra, Dan Nettleton 

Publication date: 25 October 2011

Published in: Sankhyā. Series B (Search for Journal in Brave)

Full work available at URL: https://lib.dr.iastate.edu/cgi/viewcontent.cgi?article=1074&context=stat_las_pubs

Recommendations

• A population-size model for protein spot detection in proteomic studies
• Identification of differentially expressed spatial clusters using humoral response microarray data
• A likelihood-based approach to defining statistical significance in proteomic analysis where missing data cannot be disregarded
• Bayesian identification of protein differential expression in multi-group isobaric labelled mass spectrometry data
• Analysis of dynamic protein expression data

zbMATH Keywords

Markov chain Monte CarloROC curvesEM algorithmobserved information matrixGaussian mixture modelconditional point process simulationisoelectric pointsmolecular weights

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Numerical analysis or methods applied to Markov chains (65C40) Biochemistry, molecular biology (92C40) Probabilistic models, generic numerical methods in probability and statistics (65C20) Biophysics (92C05)

Cites Work

• Title not available (Why is that?)
• Finite mixture models
• Bayesian alignment using hierarchical models, with applications in protein bioinformatics
• The EM Algorithm and Extensions, 2E
• Title not available (Why is that?)
• Convergence of a stochastic approximation version of the EM algorithm
• Maximizing Generalized Linear Mixed Model Likelihoods With an Automated Monte Carlo EM Algorithm
• An automated (Markov chain) Monte Carlo EM algorithm
• A stochastic approximation type EM algorithm for the mixture problem
• Nearest-Neighbour Markov Point Processes and Random Sets
• Numerical Issues in Statistical Computing for the Social Scientist

Cited In (5)

• A likelihood-based approach to defining statistical significance in proteomic analysis where missing data cannot be disregarded
• Finite mixture models and model-based clustering
• Analysis of dynamic protein expression data
• A population-size model for protein spot detection in proteomic studies
• Challenges in model-based clustering

Uses Software

• Pinnacle

This page was built for publication: Accounting for spot matching uncertainty in the analysis of proteomics data from two-dimensional gel electrophoresis

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q641803)