Pressure-Poisson Equation in Numerical Simulation of Cerebral Arterial Circulation and Its Effect on the Electrical Conductivity of the Brain
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Publication:6425974
arXiv2302.04814MaRDI QIDQ6425974FDOQ6425974
Authors: Maryam Samavaki, Yusuf Oluwatoki Yusuf, Arash Zarrin nia, Santtu Söderholm, Joonas Lahtinen, Fernando Galaz Prieto, S. Pursiainen 
Publication date: 9 February 2023
Abstract: Background and Objective: This study considers dynamic modelling of the cerebral arterial circulation and reconstructing an atlas for the electrical conductivity of the brain. The conductivity is a governing parameter in several electrophysiological modalities such as electroencephalography (EEG) and transcranial electrical stimulation (tES). While high-resolution 7 Tesla Magnetic Resonance Imaging (MRI) data allows for reconstructing the cerebral arteries with a cross-sectional diameter larger than the voxel size, the conductivity cannot be directly inferred from MRI data. The state-of-the-art head models applied in EEG and tES typically associate each head tissue compartment with a constant conductivity, omitting any dynamical effects of cerebral circulation. Incorporating those effects poses the challenge of solving a system of incompressible Navier-Stokes equations (NSEs) in a realistic multi-compartment head model. Methods: We propose that circulation in the distinguishable arteries can be estimated via the pressure Poisson equation (PPE). To establish a fluid exchange model between arteries and microarteries, a boundary condition derived from the Hagen-Poisseuille model is applied. The relationship between the estimated blood concentration and the tissue conductivity is approximated through Archie's law for fluid flow in porous media. Results: Through the formulation of the PPE and a set of boundary conditions based on the Hagen-Poisseuille model, we obtained an equivalent formulation of the incompressible NSEs. Thus, allowing effective blood pressure estimation in cerebral arteries segmented from open 7 Tesla MRI data. Conclusions: We developed and built a useful modeling framework that accounts for the effects of dynamic blood flow on a novel MRI-based conductivity atlas.
Navier-Stokes equations (35Q30) Finite element, Rayleigh-Ritz and Galerkin methods for boundary value problems involving PDEs (65N30) Diffusion (76R50)
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