A Wright-Fisher graph model and the impact of directional selection on genetic variation
From MaRDI portal
Publication:6426535
arXiv2302.07542MaRDI QIDQ6426535FDOQ6426535
Authors: Ingemar Kaj, Carina F. Mugal, R. Müller 
Publication date: 15 February 2023
Abstract: We introduce a multi-allele Wright-Fisher model with non-recurrent, reversible mutation and directional selection. In this setting, the allele frequencies at a single locus track the path of a hybrid jump-diffusion process with state space given by the vertex and edge set of a graph. Vertices represent monomorphic population states and edge-positions mark the biallelic proportions of ancestral and derived alleles during polymorphic segments. We derive the stationary distribution in mutation-selection-drift equilibrium and obtain the expected allele frequency spectrum under large population size scaling. For the extended model with multiple independent loci we derive rigorous upper bounds for a wide class of associated measures of genetic variation. Within this framework we present mathematically precise arguments to conclude that the presence of directional selection reduces the magnitude of genetic variation, as constrained by the bounds for neutral evolution.
Applications of Brownian motions and diffusion theory (population genetics, absorption problems, etc.) (60J70) Problems related to evolution (92D15) Jump processes on general state spaces (60J76)
This page was built for publication: A Wright-Fisher graph model and the impact of directional selection on genetic variation
Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q6426535)
