An explicit Fourier-Klibanov method for an age-dependent tumor growth model of Gompertz type

DOI10.1016/J.APNUM.2024.01.020MaRDI QIDQ6434342zbMATH OpenOpenAlexWikidataFDO

Authors Nguyen Thi Yen Ngoc, Vo Anh Khoa

Publication date 25 April 2023

Full work available at URL https://doi.org/10.1016/j.apnum.2024.01.020

Mathematics Subject Classification ID

Numerical methods for partial differential equations, initial value and time-dependent initial-boundary value problems (65Mxx) Miscellaneous topics in partial differential equations (35Rxx) Physiological, cellular and medical topics (92Cxx)

Abstract: This paper proposes an explicit Fourier-Klibanov method as a new approximation technique for an age-dependent population PDE of Gompertz type in modeling the evolution of tumor density in a brain tissue. Through suitable nonlinear and linear transformations, the Gompertz model of interest is transformed into an auxiliary third-order nonlinear PDE. Then, a coupled transport-like PDE system is obtained via an application of the Fourier-Klibanov method, and, thereby, is approximated by the explicit finite difference operators of characteristics. The stability of the resulting difference scheme is analyzed under the standard 2-norm topology. Finally, we present some computational results to demonstrate the effectiveness of the proposed method.

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