A computational framework for pharmaco-mechanical interactions in arterial walls using parallel monolithic domain decomposition methods

DOI10.1002/GAMM.202370002arXiv2307.02972OpenAlexW4390781395MaRDI QIDQ6442833FDOQ6442833

Authors: Daniel Balzani, Alexander Heinlein, Axel Klawonn, Jascha Knepper, Sharan Nurani Ramesh, Oliver Rheinbach, Lea Saßmannshausen, Klemens Uhlmann 

Publication date: 6 July 2023

Abstract: A computational framework is presented to numerically simulate the effects of antihypertensive drugs, in particular calcium channel blockers, on the mechanical response of arterial walls. A stretch-dependent smooth muscle model by Uhlmann and Balzani is modified to describe the interaction of pharmacological drugs and the inhibition of smooth muscle activation. The coupled deformation-diffusion problem is then solved using the finite element software FEDDLib and overlapping Schwarz preconditioners from the Trilinos package FROSch. These preconditioners include highly scalable parallel GDSW (generalized Dryja-Smith-Widlund) and RDSW (reduced GDSW) preconditioners. Simulation results show the expected increase in the lumen diameter of an idealized artery due to the drug-induced reduction of smooth muscle contraction, as well as a decrease in the rate of arterial contraction in the presence of calcium channel blockers. Strong and weak parallel scalability of the resulting computational implementation are also analyzed.

Full work available at URL: https://doi.org/10.1002/gamm.202370002

Mathematics Subject Classification ID

Numerical methods for partial differential equations, boundary value problems (65Nxx) Numerical linear algebra (65Fxx) Physiological, cellular and medical topics (92Cxx)

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