A first principle (3+1)-dimensional model for microtubule polymerization

DOI10.1016/J.PHYSLETA.2008.10.038MaRDI QIDQ646960zbMATH OpenOpenAlexFDO

Authors Vahid Rezania, J. A. Tuszyński

Publication date 30 November 2011

Published in Physics Letters. A (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/0810.4099

Mathematics Subject Classification ID

Pattern formations in context of PDEs (35B36) NLS equations (nonlinear Schrödinger equations) (35Q55) Statistical mechanics of polymers (82D60)

Abstract: In this paper we propose a microscopic model to study the polymerization of microtubules (MTs). Starting from fundamental reactions during MT's assembly and disassembly processes, we systematically derive a nonlinear system of equations that determines the dynamics of microtubules in 3D. %coexistence with tubulin dimers in a solution. We found that the dynamics of a MT is mathematically expressed via a cubic-quintic nonlinear Schrodinger (NLS) equation. Interestingly, the generic 3D solution of the NLS equation exhibits linear growing and shortening in time as well as temporal fluctuations about a mean value which are qualitatively similar to the dynamic instability of MTs observed experimentally. By solving equations numerically, we have found spatio-temporal patterns consistent with experimental observations.

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Cites work

• Coherent structures in strongly interacting many-body systems. I. Derivation of dynamics
• Diffusion approximation of the stochastic process of microtubule assembly
• Non-linear field dynamics of reacting nuclear, atomic and molecular species
• Solitons in Molecular Systems
• The world of the complex Ginzburg-Landau equation

Cited in

(5)

• Polymerization of microtubules in the presence of diffusing tubulins: a boundary layer analysis
• Effects of Gaussian thermal fluctuations on the thermodynamic of microtubules in Landau-Ginzburg-Wilson model
• Diffusion approximation of the stochastic process of microtubule assembly
• A theoretical framework for the biophysics of tubulins
• Stochastic model of microtubule dynamics

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