A first principle (3+1)-dimensional model for microtubule polymerization

DOI10.1016/J.PHYSLETA.2008.10.038zbMATH Open1227.35237arXiv0810.4099OpenAlexW2023845214MaRDI QIDQ646960FDOQ646960

Authors: Vahid Rezania, J. A. Tuszyński 

Publication date: 30 November 2011

Published in: Physics Letters. A (Search for Journal in Brave)

Abstract: In this paper we propose a microscopic model to study the polymerization of microtubules (MTs). Starting from fundamental reactions during MT's assembly and disassembly processes, we systematically derive a nonlinear system of equations that determines the dynamics of microtubules in 3D. %coexistence with tubulin dimers in a solution. We found that the dynamics of a MT is mathematically expressed via a cubic-quintic nonlinear Schrodinger (NLS) equation. Interestingly, the generic 3D solution of the NLS equation exhibits linear growing and shortening in time as well as temporal fluctuations about a mean value which are qualitatively similar to the dynamic instability of MTs observed experimentally. By solving equations numerically, we have found spatio-temporal patterns consistent with experimental observations.

Full work available at URL: https://arxiv.org/abs/0810.4099

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Mathematics Subject Classification ID

Pattern formations in context of PDEs (35B36) NLS equations (nonlinear Schrödinger equations) (35Q55) Statistical mechanics of polymers (82D60)

Cites Work

• Diffusion approximation of the stochastic process of microtubule assembly
• The world of the complex Ginzburg-Landau equation
• Solitons in Molecular Systems
• Non-linear field dynamics of reacting nuclear, atomic and molecular species
• Coherent structures in strongly interacting many-body systems. I. Derivation of dynamics

Cited In (5)

• Diffusion approximation of the stochastic process of microtubule assembly
• Stochastic model of microtubule dynamics
• Polymerization of microtubules in the presence of diffusing tubulins: a boundary layer analysis
• A theoretical framework for the biophysics of tubulins
• Effects of Gaussian thermal fluctuations on the thermodynamic of microtubules in Landau-Ginzburg-Wilson model

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