Kinetic chemotaxis tumbling kernel determined from macroscopic quantities
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Publication:6506014
DOI10.1137/22M1499911arXiv2206.01629MaRDI QIDQ6506014FDOQ6506014
Authors: Kathrin Hellmuth, C. Klingenberg, Qin Li, Min Tang 
Abstract: Chemotaxis is the physical phenomenon that bacteria adjust their motions according to chemical stimulus. A classical model for this phenomenon is a kinetic equation that describes the velocity jump process whose tumbling/transition kernel uniquely determines the effect of chemical stimulus on bacteria. The model has been shown to be an accurate model that matches with bacteria motion qualitatively. For a quantitative modeling, biophysicists and practitioners are also highly interested in determining the explicit value of the tumbling kernel. Due to the experimental limitations, measurements are typically macroscopic in nature. Do macroscopic quantities contain enough information to recover microscopic behavior? In this paper, we give a positive answer. We show that when given a special design of initial data, the population density, one specific macroscopic quantity as a function of time, contains sufficient information to recover the tumbling kernel and its associated damping coefficient. Moreover, we can read off the chemotaxis tumbling kernel using the values of population density directly from this specific experimental design. This theoretical result using kinetic theory sheds light on how practitioners may conduct experiments in laboratories.
Integro-partial differential equations (45K05) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Integro-partial differential equations (35R09) Inverse problems for PDEs (35R30) Cell movement (chemotaxis, etc.) (92C17)
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