A decomposition-based approach for deriving positive steady states of a class of chemical reaction networks with non-mass-action kinetics

arXiv2304.11594MaRDI QIDQ6509779FDOQ6509779

Bryan S. Hernandez, Patrick Vincent N. Lubenia

Abstract: Steady states are often used to study long-term behaviors of (bio)-chemical systems. Recently, network-based approaches have been given attention to derive parametrizations of positive steady states of these systems that follow mass-action kinetics. In this work, we consider deriving positive steady states of networks with kinetics that may include polynomials, quotients, and mixed kinetics. For instance, mixed kinetics occurs when some reactions follow the mass-action kinetics while on the other hand, some reactions within the same network follow quotient rate laws. This is the case of a complex mathematical model of insulin signaling pathway in type 2 diabetes. To derive its positive steady states, we modify our previous approach, which employs network decomposition, to handle networks with non-mass-action kinetics. Such an approach breaks a given network into smaller independent subnetworks so that we first derive the positive steady states of these subnetworks individually, and then combine them to get the positive steady states of the whole network. This makes the computation become more manageable for complex and large networks. Importantly, this could separate reactions with purely mass-action into certain subnetworks from those reactions that follow different rate laws. Finally, we also discuss the possibility of considering transformations of networks with non-mass-action kinetics and study their associated (e.g., dynamically equivalent) networks with mass-action kinetics.

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