Flexible model-based non-negative matrix factorization with application to mutational signatures

DOI10.1515/SAGMB-2023-0034MaRDI QIDQ6544880zbMATH OpenFDO

Authors Ragnhild Laursen, Lasse Maretty, Asger Hobolth

Publication date 27 May 2024

Published in Statistical Applications in Genetics and Molecular Biology (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

zbMATH Keywords

Poisson regressionnon-negative matrix factorization (NMF)cancer genomicsexpectation-maximization (EM) algorithminteraction termsmutational signatures

Mathematics Subject Classification ID

Protein sequences, DNA sequences (92D20) Pathology, pathophysiology (92C32)

Cites work

• scientific article; zbMATH DE number 47310 (Why is no real title available?)
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• A sampling algorithm to compute the set of feasible solutions for nonnegative matrix factorization with an arbitrary rank
• Choosing starting values for the EM algorithm for getting the highest likelihood in multivariate Gaussian mixture models
• To explain or to predict?

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