Neuronal activity induces symmetry breaking in neurodegenerative disease spreading

DOI10.1007/S00285-024-02103-XMaRDI QIDQ6553210zbMATH OpenFDO

Authors Christoffer G. Alexandersen, Alain Goriely, Christian Bick

Publication date 11 June 2024

Published in Journal of Mathematical Biology (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.1007/S00285-024-02103-X

zbMATH Keywords

adaptive networksAlzheimer's diseasebrain activitydynamics on networkshuman connectomemultiple time scalesneurodegenerative diseasetoxic spreading

Mathematics Subject Classification ID

Neural networks for/in biological studies, artificial life and related topics (92B20) Pathology, pathophysiology (92C32)

Review text

Slow-fast dynamics on a network are used to simulate the progression of Alzheimer's disease. The system proposed by the authors treats the different timescales arising from the protein spreading and neuronal activity, two processes which admit a feedback mechanism. The authors present their study on the dynamics of heterodimer spreading in a system of Kuramoto oscillators, and show certain neuronal oscillatory activity corresponds to toxic protein outbreaks that in turn is responsible for symmetry breaking in the spread patterns. Numerical simulations are also given.

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Cites work

• A review of the integrate-and-fire neuron model: I. Homogeneous synaptic input
• Asymmetric adaptivity induces recurrent synchronization in complex networks
• Averaging methods in nonlinear dynamical systems
• Complex dynamics in adaptive phase oscillator networks
• Economic networks: the new challenges
• Front Propagation and Arrival Times in Networks with Application to Neurodegenerative Diseases
• scientific article; zbMATH DE number 3524004 (Why is no real title available?)
• Multiple time scale dynamics
• On fast-slow consensus networks with a dynamic weight
• Parabolic Bursting in an Excitable System Coupled with a Slow Oscillation
• The role of clearance in neurodegenerative diseases

Cited in

(1)

• Oscillations in neuronal activity: a neuron-centered spatiotemporal model of the unfolded protein response in prion diseases

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