Incorporation of healthy volunteers data on receptor occupancy into a phase II proof-of-concept trial using a Bayesian dynamic borrowing design

DOI10.1002/BIMJ.202200305MaRDI QIDQ6595102zbMATH OpenFDO

Authors Fulvio Di Stefano, Christelle Rodrigues, Stephanie Galtier, Sandrine Guilleminot, Veronique Robert, Mauro Gasparini, Gaelle Saint-Hilary

Publication date 29 August 2024

Published in Biometrical Journal (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1002/BIMJ.202200305

zbMATH Keywords

Bayesianborrowingearly phasehistorical dataphase IIphysiology-based pharmacokineticsreceptor occupancy

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Cites work

• Predictive probability of success using surrogate endpoints
• Predictively consistent prior effective sample sizes
• Robust meta‐analytic‐predictive priors in clinical trials with historical control information

Cited in

(1)

• Statistical modeling to adjust for time trends in adaptive platform trials utilizing non-concurrent controls

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