An efficient therapy strategy under a novel HIV model

DOI10.1155/2011/828509MaRDI QIDQ659548zbMATH OpenOpenAlexWikidataFDO

Authors Chunming Zhang, Xiaofan Yang, Wanping Liu, Luxing Yang

Publication date 23 January 2012

Published in Discrete Dynamics in Nature and Society (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.1155/2011/828509

Mathematics Subject Classification ID

Applications of optimal control and differential games (49N90) Medical applications (general) (92C50) Medical epidemiology (92C60)

Review text

Summary: By incorporating the chemotherapy into a previous model describing the interaction of the immune system with the human immunodeficiency virus (HIV), this paper proposes a novel HIV virus spread model with control variables. Our goal is to maximize the number of healthy cells and, meanwhile, to minimize the cost of chemotherapy. In this context, the existence of an optimal control is proved. Experimental results show that, under this model, the spread of HIV virus can be controlled effectively.

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Cited in

(7)

• Fighting a virus with a virus: A dynamic model for HIV-1 therapy
• An optimal scheme to boost immunity and suppress viruses for HIV by combining a phased immunotherapy with the sustaining antiviral therapy
• Optimal strategy for controlling the spread of HIV/AIDS disease: a case study of South Africa
• Optimal control of multiple transmission of water-borne diseases
• Affinity Hemodialysis for Antiviral Therapy with Specific Application to HIV
• Optimal control strategy of HIV-1 epidemic model for recombinant virus
• Conflict and accord of optimal treatment strategies for HIV infection within and between hosts

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