Bistability in two-locus models with selection, mutation, and recombination
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Publication:663156
DOI10.1007/S00285-010-0352-XzbMATH Open1232.92060arXiv1001.1348OpenAlexW3104195973WikidataQ51681337 ScholiaQ51681337MaRDI QIDQ663156FDOQ663156
Publication date: 14 February 2012
Published in: Journal of Mathematical Biology (Search for Journal in Brave)
Abstract: The evolutionary effect of recombination depends crucially on the epistatic interactions between linked loci. A paradigmatic case where recombination is known to be strongly disadvantageous is a two-locus fitness landscape dis- playing reciprocal sign epistasis with two fitness peaks of unequal height. Focusing on the occurrence of bistability in the equilibrium solutions, we consider here the deterministic, haploid two-locus model with reversible mu- tations, selection and recombination. We find analytic formulae for the criti- cal recombination probability rc above which two stable stationary solutions appear which are localized on each of the two fitness peaks. We also derive the stationary genotype frequencies in various parameter regimes. When the recombination rate is close to rc and the fitness difference between the two peaks is small, we obtain a compact description in terms of a cubic polyno- mial which is analogous to the Landau theory of physical phase transitions.
Full work available at URL: https://arxiv.org/abs/1001.1348
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Cites Work
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Cited In (7)
- Reciprocal sign epistasis and truncation selection: when is recombination favorable in a pre-breeding program with a selfing species?
- Evolutionary Behavior in a Two-Locus System
- A nearly-neutral biallelic Moran model with biased mutation and linear and quadratic selection
- Time to fixation in the presence of recombination
- Quantifying the potential and flux landscapes of multi-locus evolution
- Dynamics of the two-locus haploid model
- Finding the boundary between evolutionary basins of attraction, and implications for Wright’s fitness landscape analogy
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