Exploration of sexual dimorphism and inter-individual variability in multivariate parameter spaces for a pharmacokinetic compartment model

DOI10.1016/J.MBS.2018.12.011MaRDI QIDQ669164zbMATH OpenOpenAlexWikidataFDO

Authors Megerle L. Scherholz, Ioannis P. Androulakis

Publication date 20 March 2019

Published in Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.mbs.2018.12.011

zbMATH Keywords

principal component analysissupport vector machinesex differencesspecial population

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Learning and adaptive systems in artificial intelligence (68T05) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

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Cites work

• A methodology for performing global uncertainty and sensitivity analysis in systems biology
• Sensitivity and Uncertainty Analysis of Complex Models of Disease Transmission: An HIV Model, as an Example

Cited in

(3)

• Inferential assessment of the MI index of sexual dimorphism: a comparative study with some other sexual dimorphism measures
• Local identifiability analysis, parameter subset selection and verification for a minimal brain PBPK model
• Assessing pharmacokinetic variability directly induced by drug intake behaviour through development of a feeding behaviour-pharmacokinetic model

Describes a project that uses

Uses Software

• Sobol

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