Minimal time spiking in various ChR2-controlled neuron models

DOI10.1007/S00285-017-1101-1zbMATH Open1383.49054arXiv1607.05625OpenAlexW2962806714WikidataQ47782777 ScholiaQ47782777MaRDI QIDQ681653FDOQ681653

Authors: Vincent Renault, Michèle Thieullen, Emmanuel Trélat 

Publication date: 12 February 2018

Published in: Journal of Mathematical Biology (Search for Journal in Brave)

Abstract: We use conductance based neuron models and the mathematical modeling of Optogenetics to define controlled neuron models and we address the minimal time control of these affine systems for the first spike from equilibrium. We apply tools of geometric optimal control theory to study singular extremals and we implement a direct method to compute optimal controls. When the system is too large to theoretically investigate the existence of singular optimal controls, we observe numerically the optimal bang-bang controls.

Full work available at URL: https://arxiv.org/abs/1607.05625

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zbMATH Keywords

optimal controlconductance-based neuron modelsminimal time affine controloptogeneticssingular extremals

Mathematics Subject Classification ID

Neural biology (92C20) Existence theories for optimal control problems involving ordinary differential equations (49J15) Existence of optimal solutions belonging to restricted classes (Lipschitz controls, bang-bang controls, etc.) (49J30) Variational principles of physics (49S05) Control/observation systems governed by ordinary differential equations (93C15)

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Cited In (9)

• Charge-balanced spike timing control for phase models of spiking neurons
• Constrained charge-balanced minimum-power controls for spiking neuron oscillators
• Optimal control of infinite-dimensional piecewise deterministic Markov processes and application to the control of neuronal dynamics via optogenetics
• A new approach to optimal control of conductance-based spiking neurons
• Control of neural synchrony using channelrhodopsin-2: a computational study
• Geometric optimal techniques to control the muscular force response to functional electrical stimulation using a non-isometric force-fatigue model
• Optimal control of input rates of Stein's models
• A new characterization of the jump rate for piecewise-deterministic Markov processes with discrete transitions
• Time optimal control of spiking neurons

Uses Software

• AMPL

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