Semiparametric theory for causal mediation analysis: efficiency bounds, multiple robustness and sensitivity analysis
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Abstract: While estimation of the marginal (total) causal effect of a point exposure on an outcome is arguably the most common objective of experimental and observational studies in the health and social sciences, in recent years, investigators have also become increasingly interested in mediation analysis. Specifically, upon evaluating the total effect of the exposure, investigators routinely wish to make inferences about the direct or indirect pathways of the effect of the exposure, through a mediator variable or not, that occurs subsequently to the exposure and prior to the outcome. Although powerful semiparametric methodologies have been developed to analyze observational studies that produce double robust and highly efficient estimates of the marginal total causal effect, similar methods for mediation analysis are currently lacking. Thus, this paper develops a general semiparametric framework for obtaining inferences about so-called marginal natural direct and indirect causal effects, while appropriately accounting for a large number of pre-exposure confounding factors for the exposure and the mediator variables. Our analytic framework is particularly appealing, because it gives new insights on issues of efficiency and robustness in the context of mediation analysis. In particular, we propose new multiply robust locally efficient estimators of the marginal natural indirect and direct causal effects, and develop a novel double robust sensitivity analysis framework for the assumption of ignorability of the mediator variable.
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Cites work
- scientific article; zbMATH DE number 1487684 (Why is no real title available?)
- Adjusting for Nonignorable Drop-Out Using Semiparametric Nonresponse Models
- Bounded, efficient and doubly robust estimation with inverse weighting
- Comment: Performance of double-robust estimators when ``inverse probability weights are highly variable
- Demystifying double robustness: a comparison of alternative strategies for estimating a population mean from incomplete data
- Doubly Robust Estimation in Missing Data and Causal Inference Models
- Estimating Exposure Effects by Modelling the Expectation of Exposure Conditional on Confounders
- Estimation of Regression Coefficients When Some Regressors Are Not Always Observed
- Estimation of a semiparametric natural direct effect model incorporating baseline covariates
- Identification, inference and sensitivity analysis for causal mediation effects
- Improving efficiency and robustness of the doubly robust estimator for a population mean with incomplete data
- Inference for semiparametric models: Some questions and an answer. (With comments)
- On protected estimation of an odds ratio model with missing binary exposure and confounders
- On the Role of the Propensity Score in Efficient Semiparametric Estimation of Average Treatment Effects
- Semiparametric theory and missing data.
- Semiparametric theory for causal mediation analysis: efficiency bounds, multiple robustness and sensitivity analysis
- The foundations of confounding in epidemiology
- Unified methods for censored longitudinal data and causality
Cited in
(60)- Interference and sensitivity analysis
- Structural nested models and G-estimation: the partially realized promise
- On semiparametric estimation of a path-specific effect in the presence of mediator-outcome confounding
- Causal Fairness Analysis: A Causal Toolkit for Fair Machine Learning
- Causal mediation analysis with multiple mediators
- A semiparametric method for evaluating causal effects in the presence of error‐prone covariates
- Robust and flexible estimation of stochastic mediation effects: a proposed method and example in a randomized trial setting
- Model selection and local geometry
- Semiparametric theory for causal mediation analysis: efficiency bounds, multiple robustness and sensitivity analysis
- Identification, inference and sensitivity analysis for causal mediation effects
- Nonparametric estimation of mediation effects with a general treatment
- Bayesian data fusion: Probabilistic sensitivity analysis for unmeasured confounding using informative priors based on secondary data
- Generalized causal mediation analysis
- On parametrization, robustness and sensitivity analysis in a marginal structural Cox proportional hazards model for point exposure
- Complier Stochastic Direct Effects: Identification and Robust Estimation
- Identification, Semiparametric Efficiency, and Quadruply Robust Estimation in Mediation Analysis with Treatment-Induced Confounding
- Causal mediation analysis for sparse and irregular longitudinal data
- Doubly robust semiparametric inference using regularized calibrated estimation with high-dimensional data
- A framework for Bayesian nonparametric inference for causal effects of mediation
- Bayesian causal mediation analysis with multiple ordered mediators
- Posttreatment Confounding in Causal Mediation Studies: A Cutting-Edge Problem and a Novel Solution via Sensitivity Analysis
- Bayesian joint modeling for causal mediation analysis with a binary outcome and a binary mediator: Exploring the role of obesity in the association between cranial radiation therapy for childhood acute lymphoblastic leukemia treatment and the long-term risk of insulin resistance
- Causal mediation analysis with a three-dimensional image mediator
- Online causal inference with application to near real-time post-market vaccine safety surveillance
- Robust inference for causal mediation analysis of recurrent event data
- A Framework for Separating Individual-Level Treatment Effects From Spillover Effects
- Multiply robust generalized estimating equations for cluster randomized trials with missing outcomes
- Mediation analysis with multiple mediators under unmeasured mediator-outcome confounding
- Multiply robust estimation of natural indirect effects with multiple ordered mediators
- Causal Mediation for Survival Data: A Unifying Approach via GLM
- A causal mediation model for longitudinal mediators and survival outcomes with an application to animal behavior
- Direct and Indirect Effects based on Changes-in-Changes
- A novel estimand to adjust for rescue treatment in randomized clinical trials
- Integrated multiple mediation analysis: a robustness-specificity trade-off in causal structure
- Robust inference on effects attributable to mediators: a controlled-direct-effect-based approach for causal effect decomposition with multiple mediators
- Direct and Indirect Effects Based on Difference-in-Differences With an Application to Political Preferences Following the Vietnam Draft Lottery
- Semiparametric Causal Mediation Analysis with Unmeasured Mediator-Outcome Confounding
- Within-person variability score-based causal inference: a two-step estimation for joint effects of time-varying treatments
- Rejoinder to “Causal mediation of semicompeting risks”
- Causal mediation analysis with sure outcomes of random events model
- Identification and robust estimation of swapped direct and indirect effects: mediation analysis with unmeasured mediator-outcome confounding and intermediate confounding
- Value Enhancement of Reinforcement Learning via Efficient and Robust Trust Region Optimization
- Bounds on direct and indirect effects under treatment/mediator endogeneity and outcome attrition
- Estimation of a semiparametric natural direct effect model incorporating baseline covariates
- A class of distribution-free models for longitudinal mediation analysis
- Mediation analysis with multiple mediators
- Causal mediation analysis in the multilevel intervention and multicomponent mediator case
- Sharp sensitivity bounds for mediation under unmeasured mediator-outcome confounding
- A note on formulae for causal mediation analysis in an odds ratio context
- Causal mediation analysis: from simple to more robust strategies for estimation of marginal natural (in)direct effects
- Bayesian inference for the causal effect of mediation
- Sensitivity analysis for unobserved confounding in causal mediation analysis allowing for effect modification, censoring and truncation
- Significance testing in non-sparse high-dimensional linear models
- Robust inference for mediated effects in partially linear models
- Robust inference on population indirect causal effects: the generalized front door criterion
- Identification and efficient estimation of the natural direct effect among the untreated
- Nonparametric estimation of natural direct and indirect effects based on inverse probability weighting
- Monte-Carlo sensitivity analysis for controlled direct effects using marginal structural models in the presence of confounded mediators
- Mediation analysis with latent factors using simultaneous group-wise and parameter-wise penalization
- Causal mediation analysis with a latent mediator
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