DNA electrophoresis studied with the cage model

DOI10.1006/JCPH.2002.7095MaRDI QIDQ697782zbMATHOpenAlexFDO

Authors A. van Heukelum, G. T. Barkema, R. H. Bisseling

Publication date 17 September 2002

Published in Journal of Computational Physics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/cond-mat/0101467

zbMATH Keywords

DNA electrophoresiscage modelpolymer reptation

Mathematics Subject Classification ID

Statistical mechanics of polymers (82D60)

Abstract: The cage model for polymer reptation, proposed by Evans and Edwards, and its recent extension to model DNA electrophoresis, are studied by numerically exact computation of the drift velocities for polymers with a length L of up to 15 monomers. The computations show the Nernst-Einstein regime (v ~ E) followed by a regime where the velocity decreases exponentially with the applied electric field strength. In agreement with de Gennes' reptation arguments, we find that asymptotically for large polymers the diffusion coefficient D decreases quadratically with polymer length; for the cage model, the proportionality coefficient is DL^2=0.175(2). Additionally we find that the leading correction term for finite polymer lengths scales as N^{-1/2}, where N=L-1 is the number of bonds.

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