Abstract: We consider quantum birth of a hot Universe in the framework of quantum qeometrodynamics in the minisuperspace model. The energy spectrum of the Universe in the pre-de-Sitter domain naturally explains the cosmic microwave background (CMB) anisotropy. The false vacuum where the Universe tunnels from the pre-de-Sitter domain is assumed to be of a Grand Unification Theory (GUT) scale. The probability of the birth of a hot Universe from a quantum level proves to be about . In the presence of matter with a negative pressure (quintessence) it is possible for open and flat universes to be born as well as closed ones.
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