Semiparametric zero-inflated modeling in multi-ethnic study of atherosclerosis (MESA)

DOI10.1214/11-AOAS534zbMATH Open1248.62215arXiv1210.0300OpenAlexW2168983908WikidataQ36950561 ScholiaQ36950561MaRDI QIDQ714376FDOQ714376

Authors: Hai Liu, Shuangge Ma, Richard Kronmal, Kung-Sik Chan 

Publication date: 21 October 2012

Published in: The Annals of Applied Statistics (Search for Journal in Brave)

Abstract: We analyze the Agatston score of coronary artery calcium (CAC) from the Multi-Ethnic Study of Atherosclerosis (MESA) using the semiparametric zero-inflated modeling approach, where the observed CAC scores from this cohort consist of high frequency of zeroes and continuously distributed positive values. Both partially constrained and unconstrained models are considered to investigate the underlying biological processes of CAC development from zero to positive, and from small amount to large amount. Different from existing studies, a model selection procedure based on likelihood cross-validation is adopted to identify the optimal model, which is justified by comparative Monte Carlo studies. A shrinkaged version of cubic regression spline is used for model estimation and variable selection simultaneously. When applying the proposed methods to the MESA data analysis, we show that the two biological mechanisms influencing the initiation of CAC and the magnitude of CAC when it is positive are better characterized by an unconstrained zero-inflated normal model. Our results are significantly different from those in published studies, and may provide further insights into the biological mechanisms underlying CAC development in humans. This highly flexible statistical framework can be applied to zero-inflated data analyses in other areas.

Full work available at URL: https://arxiv.org/abs/1210.0300

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zbMATH Keywords

model selectionshrinkagepenalized splinecardiovascular diseasecoronary artery calciumlikelihood cross-validationproportional constraint

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Medical applications (general) (92C50)

Cites Work

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• A Generalized Estimating Equation Approach for Modeling Random Length Binary Vector Data
• Two-Part Models for Analysis of Agatston Scores with Possible Proportionality Constraints
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Cited In (5)

• Two-Part Models for Analysis of Agatston Scores with Possible Proportionality Constraints
• Population-average mediation analysis for zero-inflated count outcomes
• Identification of proportionality structure with two-part models using penalization
• Collective versus individual effects in survival analysis of multiple failures
• Marginal mean models for zero-inflated count data

Uses Software

• COZIGAM
• SemiPar
• gamair

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