Integrative model-based clustering of microarray methylation and expression data
From MaRDI portal
Publication:714386
Abstract: In many fields, researchers are interested in large and complex biological processes. Two important examples are gene expression and DNA methylation in genetics. One key problem is to identify aberrant patterns of these processes and discover biologically distinct groups. In this article we develop a model-based method for clustering such data. The basis of our method involves the construction of a likelihood for any given partition of the subjects. We introduce cluster specific latent indicators that, along with some standard assumptions, impose a specific mixture distribution on each cluster. Estimation is carried out using the EM algorithm. The methods extend naturally to multiple data types of a similar nature, which leads to an integrated analysis over multiple data platforms, resulting in higher discriminating power.
Recommendations
- A robust unified approach to analyzing methylation and gene expression data
- Hierarchical mixture models for biclustering in microarray data
- The Clustering of Regression Models Method with Applications in Gene Expression Data
- Clustering of microarray data via clique partitioning
- Clustering microarray data: theoretical and practical issues
Cites work
- scientific article; zbMATH DE number 1687015 (Why is no real title available?)
- scientific article; zbMATH DE number 4100431 (Why is no real title available?)
- scientific article; zbMATH DE number 3567782 (Why is no real title available?)
- scientific article; zbMATH DE number 194758 (Why is no real title available?)
- A Quantitative Study of Gene Regulation Involved in the Immune Response of Anopheline Mosquitoes
- A new algorithm for hybrid hierarchical clustering with visualization and the bootstrap
- Bayesian Models for Gene Expression With DNA Microarray Data
- Bayesian Variable Selection in Clustering High-Dimensional Data
- Clustering Criteria and Multivariate Normal Mixtures
- Clustering Objects on Subsets of Attributes (with Discussion)
- Discrete Parameter Variation: Efficient Estimation of a Switching Regression Model
- Exploration, normalization, and summaries of high density oligonucleotide array probe level data
- Finite mixture models
- How Many Clusters? Which Clustering Method? Answers Via Model-Based Cluster Analysis
- Identification of differentially expressed genes in high-density oligonucleotide arrays accounting for the quantification limits of the technology
- Integrative model-based clustering of microarray methylation and expression data
- Model-Based Clustering, Discriminant Analysis, and Density Estimation
- Model-Based Gaussian and Non-Gaussian Clustering
- Variable selection in clustering via Dirichlet process mixture models
Cited in
(13)- Identifying heterogeneous transgenerational DNA methylation sites via clustering in beta regression
- A robust unified approach to analyzing methylation and gene expression data
- Integrative model-based clustering of microarray methylation and expression data
- iBATCGH: integrative Bayesian analysis of transcriptomic and CGH data
- Joint principal trend analysis for longitudinal high-dimensional data
- Agglomerative joint clustering of metabolic data with spike at zero: a Bayesian perspective
- On integrating multi-experiment microarray data
- Integrating functional knowledge during sample clustering for microarray data using unsupervised decision trees
- Nonlinear joint latent variable models and integrative tumor subtype discovery
- Sparse integrative clustering of multiple omics data sets
- Model-based clustering with data correction for removing artifacts in gene expression data
- Biclustering with heterogeneous variance
- Bayesian unsupervised learning with multiple data types
This page was built for publication: Integrative model-based clustering of microarray methylation and expression data
Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q714386)
