Nonparametric methodology for the time-dependent partial area under the ROC curve

DOI10.1016/J.JSPI.2011.06.025MaRDI QIDQ719481zbMATH OpenOpenAlexFDO

Authors Hung Hung, Chin-Tsang Chiang

Publication date 10 October 2011

Published in Journal of Statistical Planning and Inference (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1103.1963

zbMATH Keywords

AUCGaussian processbandwidthnonparametric estimatorpAUCsurvival timecensoring timeFPRKaplan--Meier estimatormarker-dependent censoringTPR

Mathematics Subject Classification ID

Nonparametric estimation (62G05) Asymptotic properties of nonparametric inference (62G20) Estimation in survival analysis and censored data (62N02) Applications of statistics to biology and medical sciences; meta analysis (62P10) Medical applications (general) (92C50) Nonparametric tolerance and confidence regions (62G15)

Abstract: To assess the classification accuracy of a continuous diagnostic result, the receiver operating characteristic (ROC) curve is commonly used in applications. The partial area under the ROC curve (pAUC) is one of widely accepted summary measures due to its generality and ease of probability interpretation. In the field of life science, a direct extension of the pAUC into the time-to-event setting can be used to measure the usefulness of a biomarker for disease detection over time. Without using a trapezoidal rule, we propose nonparametric estimators, which are easily computed and have closed-form expressions, for the time-dependent pAUC. The asymptotic Gaussian processes of the estimators are established and the estimated variance-covariance functions are provided, which are essential in the construction of confidence intervals. The finite sample performance of the proposed inference procedures are investigated through a series of simulations. Our method is further applied to evaluate the classification ability of CD4 cell counts on patient's survival time in the AIDS Clinical Trials Group (ACTG) 175 study. In addition, the inferences can be generalized to compare the time-dependent pAUCs between patients received the prior antiretroviral therapy and those without it.

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Cites work

• scientific article; zbMATH DE number 1818516 (Why is no real title available?)
• Asymptotic Statistics
• Estimation of a bivariate distribution function under random censorship
• Functional convergence of quantile-type frontiers with application to parametric approximations
• Maximal inequalities for degenerate U-processes with applications to optimization estimators
• Nearest neighbor estimation of a bivariate distribution under random censoring
• Non-parametric estimation for time-dependent AUC
• Nonparametric bivariate estimation with randomly censored data
• On the Strong Law of Large Numbers and Related Results for Quasi-Stationary Sequences
• Partial AUC Estimation and Regression
• Random weighting and Edgeworth expansion for the nonparametric time-dependent AUC estimator
• Regression analysis for the partial area under the ROC curve
• Semiparametric Regression for the Mean and Rate Functions of Recurrent Events
• Time‐Dependent ROC Curves for Censored Survival Data and a Diagnostic Marker

Cited in

(13)

• A new way for ranking functional data with applications in diagnostic test
• A direct method to evaluate the time-dependent predictive accuracy for biomarkers
• Review and comparison of ROC curve estimators for a time-dependent outcome with marker-dependent censoring
• Time-dependent AUC with right-censored data: a survey
• Estimation methods for time-dependent AUC models with survival data
• scientific article; zbMATH DE number 2015205 (Why is no real title available?)
• Random weighting and Edgeworth expansion for the nonparametric time-dependent AUC estimator
• A nonparametric approach for partial areas under ROC curves and ordinal dominance curves
• Non-parametric estimation for time-dependent AUC
• Time-dependent classification accuracy curve under marker-dependent sampling
• Flexible regression models for ROC and risk analysis, with or without a gold standard
• Regression analysis for the partial area under the ROC curve
• SmoothROCtime: an R package for time-dependent ROC curve estimation

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