Mathematical modelling of plasticity and phenotype switching in cancer cell populations

DOI10.1016/J.MBS.2016.11.008MaRDI QIDQ730281zbMATH OpenOpenAlexWikidataFDO

Authors Seyed Ali Madani Tonekaboni, Andrew Dhawan, Mohammad Kohandel

Publication date 27 December 2016

Published in Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.mbs.2016.11.008

zbMATH Keywords

mathematical modelcancer stem cellsstochastic methodscancer heterogeneity

Mathematics Subject Classification ID

Medical applications (general) (92C50) Genetics and epigenetics (92D10) Cell biology (92C37)

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Cites work

• A multi-phenotypic cancer model with cell plasticity
• A multicompartment mathematical model of cancer stem cell-driven tumor growth dynamics
• Cancer stem cells as the engine of unstable tumor progression
• Investigating the link between epithelial-mesenchymal transition and the cancer stem cell phenotype: a mathematical approach

Cited in

(22)

• Modeling the stem cell hypothesis: investigating the effects of cancer stem cells and TGF \(- \beta\) on tumor growth
• A kinetic theory approach for modelling tumour and macrophages heterogeneity and plasticity during cancer progression
• A computational method for solving stochastic Itô-Volterra integral equation with multi-stochastic terms
• Mathematical insights into neuroendocrine transdifferentiation of human prostate cancer cells
• Mathematical modeling and quantitative analysis of phenotypic plasticity during tumor evolution based on single-cell data
• Designing proliferating cell population models with functional targets for control by anti-cancer drugs
• Mathematical modelling of cancer stem cell-targeted immunotherapy
• A mathematical study of the impact of cell plasticity on tumour control probability
• Evolutionary dynamics of cancer: from epigenetic regulation to cell population dynamics -- mathematical model framework, applications, and open problems
• An agent-based framework of tumour heterogeneity
• Close encounters of the cell kind: the impact of contact inhibition on tumour growth and cancer models
• Mathematical characterization of heterogeneity in a cancer stem cell driven tumor growth model with nonlinear self-renewal
• The overshoot and phenotypic equilibrium in characterizing cancer dynamics of reversible phenotypic plasticity
• Investigating the link between epithelial-mesenchymal transition and the cancer stem cell phenotype: a mathematical approach
• Controlling stochasticity in epithelial-mesenchymal transition through multiple intermediate cellular states
• On tumoural growth and treatment under cellular dedifferentiation
• The effects of phenotypic plasticity on the fixation probability of mutant cancer stem cells
• Statistical inference of the rates of cell proliferation and phenotypic switching in cancer
• A Bayesian statistical analysis of stochastic phenotypic plasticity model of cancer cells
• Effect of cellular de-differentiation on the dynamics and evolution of tissue and tumor cells in mathematical models with feedback regulation
• Replicator dynamics of cancer stem cell: selection in the presence of differentiation and plasticity
• Cancer stem cell, niche and EGFR decide tumor development and treatment response: a bio-computational simulation study

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