Recent advances in mathematical modeling and statistical analysis of exocytosis in endocrine cells

DOI10.1016/J.MBS.2016.11.010MaRDI QIDQ730288zbMATH OpenOpenAlexWikidataFDO

Authors Morten Gram Pedersen, Alessia Tagliavini, Giuliana Cortese, Michela Riz, Francesco Montefusco

Publication date 27 December 2016

Published in Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL http://hdl.handle.net/11577/3209197

zbMATH Keywords

survival analysis\(\beta\)-cellshormone secretionpituitary cells\(\alpha\)-cells\(\text{Ca}^{2+}\) microdomainslarge dense-core vesiclesmixed-effects modelingsecretory granulesspatiotemporal \(\text{Ca}^{2+}\) dynamics

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Systems biology, networks (92C42) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

Recommendations

• Explicit theoretical analysis of how the rate of exocytosis depends on local control by Ca\(^{2+}\) channels
• Modeling \(\mathrm{Ca}^{2+}\) currents and buffered diffusion of \(\mathrm{Ca}^{2+}\) in human \(\beta\)-cells during voltage clamp experiments
• A mathematical study of the differential effects of two SERCA isoforms on \(\text{Ca}^{2+}\) oscillations in pancreatic islets
• The dynamics of luminal depletion and the stochastic gating of \(\operatorname{Ca}^{2 +} \)-activated \(\operatorname{Ca}^{2 +}\) channels and release sites
• Mathematical modeling of insulin secretion and the role of glucose-dependent mobilization, docking, priming and fusion of insulin granules

Cites work

• Inference for clustered data using the independence loglikelihood
• Mathematical modeling of the glucose-insulin system: a review
• Mixed-Effects Models in S and S-PLUS
• Statistical Analysis of Financial Data in S-Plus

Cited in

(5)

• INTERGRANULE FUSION IN RAT PARS INTERMEDIA CELLS
• Estimating the time course of pore expansion during the spike phase of exocytotic release in mast cells of the beige mouse
• Explicit theoretical analysis of how the rate of exocytosis depends on local control by Ca\(^{2+}\) channels
• Modeling \(\mathrm{Ca}^{2+}\) currents and buffered diffusion of \(\mathrm{Ca}^{2+}\) in human \(\beta\)-cells during voltage clamp experiments
• Modelling of energy-driven switch for glucagon and insulin secretion

Describes a project that uses

Uses Software

• MEMSS
• MASS (R)
• S-PLUS
• R

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