Recent advances in mathematical modeling and statistical analysis of exocytosis in endocrine cells

DOI10.1016/J.MBS.2016.11.010zbMATH Open1367.92049OpenAlexW2551995893WikidataQ39006601 ScholiaQ39006601MaRDI QIDQ730288FDOQ730288

Authors: Morten Gram Pedersen, Alessia Tagliavini, Giuliana Cortese, Michela Riz, Francesco Montefusco 

Publication date: 27 December 2016

Published in: Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL: http://hdl.handle.net/11577/3209197

Recommendations

• Explicit theoretical analysis of how the rate of exocytosis depends on local control by Ca\(^{2+}\) channels
• Modeling \(\mathrm{Ca}^{2+}\) currents and buffered diffusion of \(\mathrm{Ca}^{2+}\) in human \(\beta\)-cells during voltage clamp experiments
• A mathematical study of the differential effects of two SERCA isoforms on \(\text{Ca}^{2+}\) oscillations in pancreatic islets
• The dynamics of luminal depletion and the stochastic gating of \(\operatorname{Ca}^{2 +} \)-activated \(\operatorname{Ca}^{2 +}\) channels and release sites
• Mathematical modeling of insulin secretion and the role of glucose-dependent mobilization, docking, priming and fusion of insulin granules

zbMATH Keywords

survival analysis\(\beta\)-cellshormone secretionpituitary cells\(\alpha\)-cells\(\text{Ca}^{2+}\) microdomainslarge dense-core vesiclesmixed-effects modelingsecretory granulesspatiotemporal \(\text{Ca}^{2+}\) dynamics

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Systems biology, networks (92C42) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

Cites Work

• Statistical Analysis of Financial Data in S-Plus
• Mixed-Effects Models in S and S-PLUS
• Inference for clustered data using the independence loglikelihood
• Mathematical modeling of the glucose-insulin system: a review

Cited In (5)

• Estimating the time course of pore expansion during the spike phase of exocytotic release in mast cells of the beige mouse
• Explicit theoretical analysis of how the rate of exocytosis depends on local control by Ca\(^{2+}\) channels
• Modeling \(\mathrm{Ca}^{2+}\) currents and buffered diffusion of \(\mathrm{Ca}^{2+}\) in human \(\beta\)-cells during voltage clamp experiments
• Modelling of energy-driven switch for glucagon and insulin secretion
• INTERGRANULE FUSION IN RAT PARS INTERMEDIA CELLS

Uses Software

• R
• S-PLUS
• MASS (R)
• MEMSS

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