Timescale analysis of a mathematical model of acetaminophen metabolism and toxicity

DOI10.1016/J.JTBI.2015.08.021MaRDI QIDQ739799zbMATH OpenOpenAlexWikidataFDO

Authors D. Kharzeev

Publication date 19 August 2016

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.1016/j.jtbi.2015.08.021

zbMATH Keywords

modellingmetabolismanalysistoxicologyacetaminophen

Mathematics Subject Classification ID

Medical applications (general) (92C50) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

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Cites work

• Global sensitivity analysis: The primer
• The role of skeletal muscle in liver glutathione metabolism during acetaminophen overdose

Cited in

(11)

• Mathematical modelling of methanol poisoning with impulsive dosing of antidote therapeutics to prevent toxicity
• Use of mathematical modeling for estimation of the toxic action of some medical agents
• Predicting tyrosinaemia: a mathematical model of 4-hydroxyphenylpyruvate dioxygenase inhibition by nitisinone in rats
• Algorithmic reduction of biological networks with multiple time scales
• The role of alcohol consumption on acetaminophen induced liver injury: implications from a mathematical model
• Impulsive differential equation model in methanol poisoning detoxification. Efficacy of activated charcoal antidote in combating methanol poisoning
• Mathematical modelling of a liver hollow fibre bioreactor
• Impulsive mathematical modeling of ascorbic acid metabolism in healthy subjects
• The role of skeletal muscle in liver glutathione metabolism during acetaminophen overdose
• SimLivA-modeling ischemia-reperfusion injury in the liver: a first step towards a clinical decision support tool
• Mathematical modelling of chronic acetaminophen metabolism and liver injury

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