The Green's function formalism as a bridge between single- and multi-compartmental modeling
From MaRDI portal
(Redirected from Publication:740630)
Abstract: Neurons are spatially extended structures that receive and process inputs on their dendrites. It is generally accepted that neuronal computations arise from the active integration of synaptic inputs along a dendrite between the input location and the location of spike generation in the axon initial segment. However, many application such as simulations of brain networks, use point-neurons --neurons without a morphological component-- as computational units to keep the conceptual complexity and computational costs low. Inevitably, these applications thus omit a fundamental property of neuronal computation. In this work, we present an approach to model an artificial synapse that mimics dendritic processing without the need to explicitly simulate dendritic dynamics. The model synapse employs an analytic solution for the cable equation to compute the neuron's membrane potential following dendritic inputs. Green's function formalism is used to derive the closed version of the cable equation. We show that by using this synapse model, point-neurons can achieve results that were previously limited to the realms of multi-compartmental models. Moreover, a computational advantage is achieved when only a small number of simulated synapses impinge on a morphologically elaborate neuron. Opportunities and limitations are discussed.
Recommendations
- A sparse reformulation of the Green's function formalism allows efficient simulations of morphological neuron models
- Dynamics of compartmental model neurons
- Computational convergence of the path integral for real dendritic morphologies
- An equivalent cable model for neuronal trees with active membrane
- Response functions for electrically coupled neuronal network: a method of local point matching and its applications
Cites work
- A simple vector implementation of the Laplace-transformed cable equations in passive dendritic trees
- An equivalent cable model for neuronal trees with active membrane
- Exact digital simulation of time-invariant linear systems with applications to neuronal modeling
- scientific article; zbMATH DE number 3138094 (Why is no real title available?)
- scientific article; zbMATH DE number 193095 (Why is no real title available?)
Cited in
(3)- Response functions for electrically coupled neuronal network: a method of local point matching and its applications
- A Green's function method for simulation of time-dependent solute transport and reaction in realistic microvascular geometries
- A sparse reformulation of the Green's function formalism allows efficient simulations of morphological neuron models
This page was built for publication: The Green's function formalism as a bridge between single- and multi-compartmental modeling
Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q740630)
