Applications of Pick-Nevanlinna interpolation theory to retention- solubility studies in the lungs

DOI10.1016/0025-5564(82)90040-2MaRDI QIDQ788657zbMATH OpenOpenAlexFDO

Authors John W. Evans, J. William Helton

Publication date 1983

Published in Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/0025-5564(82)90040-2

zbMATH Keywords

data feasibilityextreme properties of lung modelsparallel ventilation and perfusion modelPick-Nevanlinna interpolation theoryretention functionsretention-solubility studies

Mathematics Subject Classification ID

Moment problems and interpolation problems in the complex plane (30E05) Computational methods for problems pertaining to biology (92-08) Physiological, cellular and medical topics (92Cxx)

Review text

Under steady state conditions in a subject receiving an inert test gas in dissolved form by constant intravenous drip the fraction of the gas retained in the blood after a pass through the lungs is called the retention of the gas, and the dependence of this retention on test gas solubility is called the retention-solubility relation. A widely used model for this relation is the parallel ventilation and perfusion model, in which a set number of compartments are assumed to be ventilated and perfused in parallel, with test gas at equilibrium in each compartment and with fluctuations due to cyclical breathing and blood flow averaged out. It is known that such a parallel system may be regarded as an equivalent diagonalized version of more general compartmental models. In this paper the classical interpolation theory for analytic functions of Pick and Nevanlinna is shown to yield computational techniques of considerable utility in analyzing retention-solubility studies in terms of the above parallel model. At the beginning, a derivation of the retention-solubility relation for parallel lung models is given and this leads to the definition of retention functions. Further, the inverse problem is outlined and the main results of this paper are indicated: computational procedures for determining data feasibility and some properties of lung models compatible with given data. The remaining sections are devoted to the development of basic tools, the classification of data points and proofs. Some new mathematical results, of interest, concerning the class of functions are obtained.

Recommendations

• Extremal properties of lung models in retention-solubility studies
• Nevanlinna-Pick interpolation with boundary data
• scientific article; zbMATH DE number 1492796
• Parallel algorithms for nevanlinna-pick interpolation:the scalar case^∗
• Interpolation problems of Pick-Nevanlinna and Loewner types for meromorphic matrix functions: Parametrization of the set of all solutions

Cites work

• An elementary proof of the Pick-Nevanlinna interpolation theorem
• scientific article; zbMATH DE number 3613366 (Why is no real title available?)
• scientific article; zbMATH DE number 3437485 (Why is no real title available?)
• scientific article; zbMATH DE number 3219899 (Why is no real title available?)
• scientific article; zbMATH DE number 3278338 (Why is no real title available?)
• Non-Euclidean functional analysis and electronics
• Numerical algorithms for the Nevanlinna-Pick problem
• On steady state inert gas exchange
• Rational Chebyshev approximation on the unit disk

Cited in

(2)

• Extremal properties of lung models in retention-solubility studies
• Non-Euclidean functional analysis and electronics

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