Optimal control of radiation therapy in a heterogeneous population model of tumor cells

MaRDI QIDQ804502zbMATH OpenFDO

Authors S. A. Aĭrapetov, V. K. Ivanov

Publication date 1990

Published in Automation and Remote Control (Search for Journal in Brave)

zbMATH Keywords

radiation therapytumor cellsclinical radiobiologygrowth kineticsirradiation schedulesoptimal therapy controlradiation resistanceradiation sensitivitysecondary hypoxia effect

Mathematics Subject Classification ID

Medical applications (general) (92C50) Applications of optimal control and differential games (49N90)

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(15)

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• Mathematical modeling of the role of \textit{survivin} on dedifferentiation and radioresistance in cancer
• Perturbed models for cancer treatment by radiotherapy
• Additive damage models for cellular pharmacodynamics of radiation-chemotherapy combinations
• Development of a state-space water-level control for an array of cells to be employed as compensator in radiotherapy
• Optimization of radiation tumor therapy with photon and corpuscular beams
• On the optimal control of cancer radiotherapy for non-homogeneous cell populations
• Optimal control for a bone metastasis with radiotherapy model using a linear objective functional
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