Asymptotic behaviour of nonlinear semigroup describing a model of selective cell growth regulation

asymptotic behavior cell cycle regulation cell division extinction functional integral equation model Heaviside function proliferation selective growth regulation semigroup of nonlinear positive operators spectral radius stability of equilibrium survival

Mathematics Subject Classification ID

Semigroups of nonlinear operators (47H20) Nonlinear spectral theory, nonlinear eigenvalue problems (47J10) Biochemistry, molecular biology (92C40) Physiological, cellular and medical topics (92C99) Population dynamics (general) (92D25)

Review text

The model considered by the authors concerns a particular regulation of a cell population and is described by the following equation: \[ n(t,y)=2\lambda H\{\pi [N(t)]-y\}\int^{\infty}_{0}f[y,\phi (z)]n[t- \psi (z),z]dz, \] where n is a cell density, H a sigmoidal smooth approximation of the Heaviside function, \(\lambda\) is the probability of a correct cell division, \(\pi\) is a decreasing function of the total number of cycling cells, f is the density of a conditional probability distribution, and \(\phi\) and \(\psi\) are connected with the duration of the cycle and the cell mass. The main part of the paper is devoted to the study of the asymptotic behavior of the solutions of the model and this gives rise to survival or extinction cases. The methods employed in this investigation are those of the nonlinear semigroup theory.

Recommendations

Cites work

Cited in

(10)

This page was built for publication: Asymptotic behaviour of nonlinear semigroup describing a model of selective cell growth regulation

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q805519)