Sample size determination for step-down multiple test procedures: Orthogonal contrasts and comparisons with a control
We address the problem of sample size determination for step-down multiple comparison procedures (MCP's) for two nonhierarchical families - orthogonal contrasts and comparisons with a control, in order to guarantee a specified requirement on their power. The results for the corresponding single-step MCP's are obtained as special cases. In the process of determining the smallest total sample size for each MCP to guarantee the specified power requirement, we also determine the optimum allocation of this sample size among the treatments and the control.
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