The liability threshold model for censored twin data
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Abstract: Family studies provide an important tool for understanding etiology of diseases, with the key aim of discovering evidence of family aggregation and to determine if such aggregation can be attributed to genetic components. Heritability and concordance estimates are routinely calculated in twin studies of diseases, as a way of quantifying such genetic contribution. The endpoint in these studies are typically defined as occurrence of a disease versus death without the disease. However, a large fraction of the subjects may still be alive at the time of follow-up without having experienced the disease thus still being at risk. Ignoring this right-censoring can lead to severely biased estimates. We propose to extend the classical liability threshold model with inverse probability of censoring weighting of complete observations. This leads to a flexible way of modeling twin concordance and obtaining consistent estimates of heritability. We apply the method in simulations and to data from the population based Danish twin cohort where we describe the dependence in prostate cancer occurrence in twins.
Recommendations
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- The latent class twin method
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- Statistical Inference in Mixed Models and Analysis of Twin and Family Data
- A Bivariate Frailty Model with a Cure Fraction for Modeling Familial Correlations in Diseases
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Cited in
(9)- Population attributable fraction as a measure of heritability in dichotomous twin data
- Simulation study on the properties of quantitative trait model estimation in twin study design of normally-distributed and discrete event-time phenotype variables
- mets
- Special issue on advances in survival analysis
- Old age disability and genetics: investigation on longitudinal twin data
- Estimating heritability for cause specific mortality based on twin studies
- The latent class twin method
- Extended Bayesian model averaging for heritability in twin studies
- Genetic Susceptibility to Prostate, Breast, and Colorectal Cancer among Nordic Twins
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