The liability threshold model for censored twin data

DOI10.1016/J.CSDA.2015.01.014zbMATH Open1468.62081arXiv1407.1682OpenAlexW3021297526WikidataQ61637188 ScholiaQ61637188MaRDI QIDQ80888FDOQ80888

Jacob B. Hjelmborg, Klaus Kähler Holst, Klaus Kähler Holst, Jacob B. Hjelmborg, Thomas H. Scheike

Publication date: January 2016

Published in: Computational Statistics and Data Analysis (Search for Journal in Brave)

Abstract: Family studies provide an important tool for understanding etiology of diseases, with the key aim of discovering evidence of family aggregation and to determine if such aggregation can be attributed to genetic components. Heritability and concordance estimates are routinely calculated in twin studies of diseases, as a way of quantifying such genetic contribution. The endpoint in these studies are typically defined as occurrence of a disease versus death without the disease. However, a large fraction of the subjects may still be alive at the time of follow-up without having experienced the disease thus still being at risk. Ignoring this right-censoring can lead to severely biased estimates. We propose to extend the classical liability threshold model with inverse probability of censoring weighting of complete observations. This leads to a flexible way of modeling twin concordance and obtaining consistent estimates of heritability. We apply the method in simulations and to data from the population based Danish twin cohort where we describe the dependence in prostate cancer occurrence in twins.

Full work available at URL: https://arxiv.org/abs/1407.1682

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zbMATH Keywords

heritabilitycompeting risksprobit modelcumulative incidenceliability-thresholdpolygenic modelrandom effectsright censoringtwins

Mathematics Subject Classification ID

Computational methods for problems pertaining to statistics (62-08) Estimation in survival analysis and censored data (62N02) Applications of statistics to biology and medical sciences; meta analysis (62P10)

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Cited In (4)

• Special issue on advances in survival analysis
• Old age disability and genetics: investigation on longitudinal twin data
• mets
• Genetic Susceptibility to Prostate, Breast, and Colorectal Cancer among Nordic Twins

Uses Software

• cmprsk
• mets
• QSIMVN

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