Electrodiffusion with calcium-activated potassium channels in dendritic spine
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Abstract: We investigate calcium signaling feedback through calcium-activated potassium channels of a dendritic spine by applying the immersed boundary method with electrodiffusion. We simulate the stochastic gating of such ion channels and the resulting spatial distribution of concentration, current, and membrane voltage within the dendritic spine. In this simulation, the permeability to ionic flow across the membrane is regulated by the amplitude of chemical potential barriers. With spatially localized ion channels, chemical potential barriers are locally and stochastically regulated. This regulation represents the ion channel gating with multiple subunits, the open and closed states governed by a continuous-time Markov process. The model simulation recapitulates an inhibitory action on voltage-sensitive calcium channels by the calcium-activated potassium channels in a stochastic manner as a emph{non-local} feedback loop. The model predicts amplified calcium influx with more closely placed channel complexes, proposing a potential mechanism of differential calcium handling by channel distributions. This work provides a foundation for future computer simulation studies of dendritic spine motility and structural plasticity.
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Cited in
(13)- Competitive calcium binding: Implications for dendritic calcium signaling
- Role of calcium electrogenesis in apical dendrites: Generation of intrinsic oscillations by an axial current
- Diffusion laws in dendritic spines
- Electrodiffusion models of synaptic potentials in dendritic spines
- Propagation of CaMKII translocation waves in heterogeneous spiny dendrites
- Spike propagation in dendrites with stochastic ion channels
- Computer simulation of voltage sensitive calcium ion channels in a dendritic spine
- Stochastic amplification of calcium-activated potassium currents in Ca\(^{2+}\) microdomains
- Modeling Calcium Dynamics in Dendritic Spines
- Calcium dynamics in dendritic spines: a link to structural plasticity
- Active gating: rocking diffusion channels
- Ion-concentration gradients induced by synaptic input increase the voltage depolarization in dendritic spines
- Ca\({}^{2+}\) diffusion in a nerve terminal
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