Electrodiffusion with calcium-activated potassium channels in dendritic spine

DOI10.1007/S11538-020-00854-4zbMATH Open1466.92025arXiv1909.12449OpenAlexW3129776093WikidataQ113900207 ScholiaQ113900207MaRDI QIDQ829288FDOQ829288

Authors: Pilhwa Lee 

Publication date: 5 May 2021

Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)

Abstract: We investigate calcium signaling feedback through calcium-activated potassium channels of a dendritic spine by applying the immersed boundary method with electrodiffusion. We simulate the stochastic gating of such ion channels and the resulting spatial distribution of concentration, current, and membrane voltage within the dendritic spine. In this simulation, the permeability to ionic flow across the membrane is regulated by the amplitude of chemical potential barriers. With spatially localized ion channels, chemical potential barriers are locally and stochastically regulated. This regulation represents the ion channel gating with multiple subunits, the open and closed states governed by a continuous-time Markov process. The model simulation recapitulates an inhibitory action on voltage-sensitive calcium channels by the calcium-activated potassium channels in a stochastic manner as a emph{non-local} feedback loop. The model predicts amplified calcium influx with more closely placed channel complexes, proposing a potential mechanism of differential calcium handling by channel distributions. This work provides a foundation for future computer simulation studies of dendritic spine motility and structural plasticity.

Full work available at URL: https://arxiv.org/abs/1909.12449

Recommendations

• Computer simulation of voltage sensitive calcium ion channels in a dendritic spine
• Modeling Calcium Dynamics in Dendritic Spines
• Calcium dynamics in dendritic spines: a link to structural plasticity
• Electrodiffusion models of synaptic potentials in dendritic spines
• Stochastic amplification of calcium-activated potassium currents in Ca\(^{2+}\) microdomains

zbMATH Keywords

immersed boundary methodcontinuous-time Markov processcalcium-activated potassium channeldendritic spineelectrodiffusionvoltage-sensitive calcium channel

Mathematics Subject Classification ID

Physiology (general) (92C30)

Cites Work

• Title not available (Why is that?)
• Title not available (Why is that?)
• The immersed boundary method
• The immersed boundary method for advection-electrodiffusion with implicit timestepping and local mesh refinement
• A three-dimensional model of cellular electrical activity
• Drift-diffusion simulation of the ephaptic effect in the triad synapse of the retina
• Steady-state voltage distribution in three-dimensional cusp-shaped funnels modeled by PNP
• Computer simulation of voltage sensitive calcium ion channels in a dendritic spine

Cited In (11)

• Calcium dynamics in dendritic spines: a link to structural plasticity
• Ion-concentration gradients induced by synaptic input increase the voltage depolarization in dendritic spines
• Modeling Calcium Dynamics in Dendritic Spines
• Active gating: rocking diffusion channels
• Computer simulation of voltage sensitive calcium ion channels in a dendritic spine
• Propagation of CaMKII translocation waves in heterogeneous spiny dendrites
• Ca\({}^{2+}\) diffusion in a nerve terminal
• Electrodiffusion models of synaptic potentials in dendritic spines
• Diffusion laws in dendritic spines
• Spike propagation in dendrites with stochastic ion channels
• Stochastic amplification of calcium-activated potassium currents in Ca\(^{2+}\) microdomains

Uses Software

• hypre
• PETSc

This page was built for publication: Electrodiffusion with calcium-activated potassium channels in dendritic spine

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q829288)