Spectral dynamic causal modelling of resting-state fMRI: an exploratory study relating effective brain connectivity in the default mode network to genetics

DOI10.1515/SAGMB-2019-0058MaRDI QIDQ830647zbMATH OpenOpenAlexWikidataFDO

Authors Yunlong Nie, Eugene Opoku, Laila Yasmin, Yin Song, Jie Wang, Sidi Wu, Vanessa Scarapicchia, Jodie Gawryluk, Jiguo Cao, Farouk S. Nathoo, L. Wang

Publication date 7 May 2021

Published in Statistical Applications in Genetics and Molecular Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1901.09975

zbMATH Keywords

parametric bootstrapimaging geneticseffective brain connectivityfunction-on-scalar regressionlongitudinal resting-state fMRIspectral dynamic causal modeling

Mathematics Subject Classification ID

Biomedical imaging and signal processing (92C55) Neural networks for/in biological studies, artificial life and related topics (92B20)

Abstract: We conduct an imaging genetics study to explore how effective brain connectivity in the default mode network (DMN) may be related to genetics within the context of Alzheimer's disease and mild cognitive impairment. We develop an analysis of longitudinal resting-state functional magnetic resonance imaging (rs-fMRI) and genetic data obtained from a sample of 111 subjects with a total of 319 rs-fMRI scans from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database. A Dynamic Causal Model (DCM) is fit to the rs-fMRI scans to estimate effective brain connectivity within the DMN and related to a set of single nucleotide polymorphisms (SNPs) contained in an empirical disease-constrained set which is obtained out-of-sample from 663 ADNI subjects having only genome-wide data. We examine longitudinal data in both a 4-region and an 6-region network and relate longitudinal effective brain connectivity networks estimated using spectral DCM to SNPs using both linear mixed effect (LME) models as well as function-on-scalar regression (FSR). In the former case we implement a parametric bootstrap for testing SNP coefficients and make comparisons with p-values obtained from the chi-squared null distribution. We also implement a parametric bootstrap approach for testing regression functions in FSR and we make comparisons between p-values obtained from the parametric bootstrap to p-values obtained using the F-distribution with degrees-of-freedom based on Satterthwaite's approximation. In both networks we report on exploratory patterns of associations with relatively high ranks that exhibit stability to the differing assumptions made by both FSR and LME.

Recommendations

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Cites work

• scientific article; zbMATH DE number 720689 (Why is no real title available?)
• scientific article; zbMATH DE number 2148841 (Why is no real title available?)
• A review of statistical methods in imaging genetics
• An Integrative Bayesian Modeling Approach to Imaging Genetics
• Bayes Factors
• Bayesian generalized low rank regression models for neuroimaging phenotypes and genetic markers

Cited in

(1)

• Statistical methods and challenges in connectome genetics

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