Spectral dynamic causal modelling of resting-state fMRI: an exploratory study relating effective brain connectivity in the default mode network to genetics

DOI10.1515/SAGMB-2019-0058zbMATH Open1461.92051arXiv1901.09975OpenAlexW3082808948WikidataQ99633648 ScholiaQ99633648MaRDI QIDQ830647FDOQ830647

Vanessa Scarapicchia, Jiguo Cao, Farouk S. Nathoo, Jie Wang, Eugene Opoku, Jodie Gawryluk, Yunlong Nie, L. Wang, Sidi Wu, Yin Song, Laila Yasmin

Publication date: 7 May 2021

Published in: Statistical Applications in Genetics and Molecular Biology (Search for Journal in Brave)

Abstract: We conduct an imaging genetics study to explore how effective brain connectivity in the default mode network (DMN) may be related to genetics within the context of Alzheimer's disease and mild cognitive impairment. We develop an analysis of longitudinal resting-state functional magnetic resonance imaging (rs-fMRI) and genetic data obtained from a sample of 111 subjects with a total of 319 rs-fMRI scans from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database. A Dynamic Causal Model (DCM) is fit to the rs-fMRI scans to estimate effective brain connectivity within the DMN and related to a set of single nucleotide polymorphisms (SNPs) contained in an empirical disease-constrained set which is obtained out-of-sample from 663 ADNI subjects having only genome-wide data. We examine longitudinal data in both a 4-region and an 6-region network and relate longitudinal effective brain connectivity networks estimated using spectral DCM to SNPs using both linear mixed effect (LME) models as well as function-on-scalar regression (FSR). In the former case we implement a parametric bootstrap for testing SNP coefficients and make comparisons with p-values obtained from the chi-squared null distribution. We also implement a parametric bootstrap approach for testing regression functions in FSR and we make comparisons between p-values obtained from the parametric bootstrap to p-values obtained using the F-distribution with degrees-of-freedom based on Satterthwaite's approximation. In both networks we report on exploratory patterns of associations with relatively high ranks that exhibit stability to the differing assumptions made by both FSR and LME.

Full work available at URL: https://arxiv.org/abs/1901.09975

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zbMATH Keywords

parametric bootstrapimaging geneticseffective brain connectivityfunction-on-scalar regressionlongitudinal resting-state fMRIspectral dynamic causal modeling

Mathematics Subject Classification ID

Biomedical imaging and signal processing (92C55) Neural networks for/in biological studies, artificial life and related topics (92B20)

Cites Work

• Title not available (Why is that?)
• Bayes Factors
• Bayesian Generalized Low Rank Regression Models for Neuroimaging Phenotypes and Genetic Markers
• Title not available (Why is that?)
• An Integrative Bayesian Modeling Approach to Imaging Genetics
• A review of statistical methods in imaging genetics

Uses Software

• PLINK
• Lmertest
• bgsmtr
• BET

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