The effects of adaptation on maximum likelihood inference for nonlinear models with normal errors

DOI10.1016/J.JSPI.2021.02.002zbMATH Open1465.62124OpenAlexW3132407324MaRDI QIDQ830758FDOQ830758

Chiara Tommasi, Nancy Flournoy, Caterina May

Publication date: 7 May 2021

Published in: Journal of Statistical Planning and Inference (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jspi.2021.02.002

zbMATH Keywords

nonlinear regressionexponential modelstable convergenceEmax modelGaussian scale mixturestwo-stage adaptive optimal design

Mathematics Subject Classification ID

Asymptotic properties of parametric estimators (62F12) General nonlinear regression (62J02) Optimal statistical designs (62K05)

Cites Work

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• Assessing the accuracy of the maximum likelihood estimator: Observed versus expected Fisher information
• Optimal designs for the emax, log-linear and exponential models
• The Sequential Generation of $D$-Optimum Experimental Designs
• Information in a two-stage adaptive optimal design
• Conditional independence, conditional mixing and conditional association
• Adaptive designs for selecting drug combinations based on efficacy-toxicity response
• Two-stage adaptive optimal design with fixed first-stage sample size
• Design of experiments in nonlinear models. Asymptotic normality, optimality criteria and small-sample properties
• Stable Convergence and Stable Limit Theorems
• Random Measures, Theory and Applications
• Random norming AIDS analysis of non-linear regression models with sequential informative dose selection

Cited In (2)

• Nonlinear Experiments: Optimal Design and Inference Based on Likelihood
• Inference for a two-stage enrichment design

Uses Software

• SAS
• DoseFinding

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