Run and tumble chemotaxis in a shear flow: the effect of temporal comparisons, persistence, rotational diffusion, and cell shape

DOI10.1007/S11538-009-9395-9zbMATH Open1168.92009arXiv0804.2352OpenAlexW2028973563WikidataQ51852751 ScholiaQ51852751MaRDI QIDQ836211FDOQ836211

Authors: J. T. Locsei, T. J. Pedley 

Publication date: 31 August 2009

Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)

Abstract: Escherichia coli is a motile bacterium that moves up a chemoattractant gradient by performing a biased random walk composed of alternating runs and tumbles. This paper presents calculations of the chemotactic drift velocity vd (the mean velocity up the chemoattractant gradient) of an E. coli cell performing chemotaxis in a uniform, steady shear flow, with a weak chemoattractant gradient at right angles to the flow. Extending earlier models, a combined analytic and numerical approach is used to assess the effect of several complications, namely (i) a cell cannot detect a chemoattractant gradient directly but rather makes temporal comparisons of chemoattractant concentration, (ii) the tumbles exhibit persistence of direction, meaning that the swimming directions before and after a tumble are correlated, (iii) the cell suffers random re-orientations due to rotational Brownian motion, and (iv) the non-spherical shape of the cell affects the way that it is rotated by the shear flow. These complications influence the dependence of vd on the shear rate gamma. When they are all included, it is found that (a) shear disrupts chemotaxis and shear rates beyond gamma = 2/second cause the cell to swim down the chemoattractant gradient rather than up it, (b) in terms of maximising drift velocity, persistence of direction is advantageous in a quiescent fluid but disadvantageous in a shear flow, and (c) a more elongated body shape is advantageous in performing chemotaxis in a strong shear flow.

Full work available at URL: https://arxiv.org/abs/0804.2352

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zbMATH Keywords

random walkchemotaxisshear flowEscherichia coli

Mathematics Subject Classification ID

Monte Carlo methods (65C05) Signal detection and filtering (aspects of stochastic processes) (60G35) Brownian motion (60J65) Cell movement (chemotaxis, etc.) (92C17) Cell biology (92C37)

Cites Work

• Cuba -- a library for multidimensional numerical integration
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• Modelling run-and-tumble chemotaxis in a shear flow
• Persistence of direction increases the drift velocity of run and tumble chemotaxis
• Flagellar Hydrodynamics
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• From Signal Transduction to Spatial Pattern Formation inE. coli: A Paradigm for Multiscale Modeling in Biology
• The motion of rigid particles in a shear flow at low Reynolds number
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Cited In (11)

• Theoretical results for chemotactic response and drift of \textit{E. coli} in a weak attractant gradient
• A path-integral characterization of run and tumble motion and chemotaxis of bacteria
• Sensitivity of the rate of nutrient uptake by chemotactic bacteria to physical and biological parameters in a turbulent environment
• Modelling run-and-tumble chemotaxis in a shear flow
• Persistence of direction increases the drift velocity of run and tumble chemotaxis
• Directional persistence and the optimality of run-and-tumble chemotaxis
• The role of tumbling frequency and persistence in optimal run-and-tumble chemotaxis
• The wiggling trajectories of bacteria
• A model of strongly biased chemotaxis reveals the trade-offs of different bacterial migration strategies
• A note on the motion of an Ocean Bacterium in a Linear Shear Flow
• Stochastic dynamics of active swimmers in linear flows

Uses Software

• Cuba

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