Geometry and topology of parameter space: Investigating measures of robustness in regulatory networks

DOI10.1007/S00285-008-0230-YzbMATH Open1231.92035OpenAlexW2058618427WikidataQ41872175 ScholiaQ41872175MaRDI QIDQ843306FDOQ843306

Authors: Madalena Chaves, Anirvan Sengupta, Eduardo D. Sontag 

Publication date: 12 October 2009

Published in: Journal of Mathematical Biology (Search for Journal in Brave)

Full work available at URL: http://europepmc.org/articles/pmc3034167

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Mathematics Subject Classification ID

Systems biology, networks (92C42) Sensitivity (robustness) (93B35) Computational methods for problems pertaining to biology (92-08) Geometric methods (93B27)

Cites Work

• Title not available (Why is that?)
• Partial cylindrical algebraic decomposition for quantifier elimination
• Title not available (Why is that?)
• Cylindrical Algebraic Decomposition I: The Basic Algorithm
• Symbolic reachability computation for families of linear vector fields

Cited In (14)

• Quantification of degeneracy in biological systems for characterization of functional interactions between modules
• Quantifying robustness of the gap gene network
• Robustness and fragility of Boolean models for genetic regulatory networks
• A mathematical study of the robustness of G2/M regulatory network in response to DNA damage with parameters sensitivity
• The influence of assortativity on the robustness of signal-integration logic in gene regulatory networks
• Steady-state robustness of qualitative gene regulation networks
• Uncovering the design principles of circadian clocks: mathematical analysis of flexibility and evolutionary goals
• Connectivity of parameter regions of multistationarity for multisite phosphorylation networks
• Chaotic gene regulatory networks can be robust against mutations and noise
• A general mechanism for network-dosage compensation in gene circuits
• Invalidation of the structure of genetic network dynamics: a geometric approach
• On the interplay between entropy and robustness of gene regulatory networks
• Reaction network models as a tool to study gene regulation and cell signaling in development and diseases
• Robustness of complex feedback systems: application to oncological biochemical networks

Uses Software

• Mathematica
• QEPCAD

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