Abstract: Results on characterization of manifolds in terms of certain Lie algebras growing on them, especially Lie algebras of differential operators, are reviewed and extended. In particular, we prove that a smooth (real-analytic, Stein) manifold is characterized by the corresponding Lie algebra of linear differential operators, i.e. isomorphisms of such Lie algebras are induced by the appropriate class of diffeomorphisms of the underlaying manifolds.
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