Fluid-retention side-effects of the chemotherapy-supportive treatment interleukin-11: mathematical modelling of putative underlying mechanisms

DOI10.1080/10273660600969018MaRDI QIDQ883746zbMATH OpenOpenAlexFDO

Authors Yuri Kheifetz, Moran Elishmereni, Smadar Horowitz, Zvia Agur

Publication date 12 June 2007

Published in Computational \& Mathematical Methods in Medicine (Search for Journal in Brave)

Full work available at URL https://eudml.org/doc/233311

zbMATH Keywords

anti-inflammation therapyblood volume expansioncytokine therapyincomplete inverse problemordinary differential equationsthrombocytopenia

Mathematics Subject Classification ID

Physiological flow (92C35) Medical applications (general) (92C50)

Review text

Summary: Interleukin-11 (IL-11) is a pleiotropic thrombopoietic cytokine and immune modulator, clinically approved for alleviation of chemotherapy-induced thrombocytopenia in non-myeloid malignancies. IL-11 therapy exerts fluid accumulation-associated adverse effects, complicating its administration and limiting its use. Implementation of standard biomathematical techniques to assess these effects is not possible, due to incomplete knowledge of the underlying mechanisms. This study investigates IL-11-induced blood volume expansion (BVE) by a new mathematical modelling methodology. Alternative models for BVE following IL-11 therapy were constructed, calibrated with clinical information and simulated in a number of treatment scenarios. The models demonstrated high compliance and were equally capable of reliably predicting BVE in a wide range of treatments, provided sufficient data. Model simulations indicate that frequent and low dose IL-11 regimens are favored for ensuring minimal fluid retention, upon the current IL-11 therapy.

Recommendations

• Modelling of peripheral fluid accumulation after a crystalloid bolus in female volunteers. A mathematical study
• Mathematical model for G-CSF administration after chemotherapy
• Characterizing chemotherapy-induced neutropenia and monocytopenia through mathematical modelling
• Immunotherapy with Interleukin-2: A Study Based on Mathematical Modeling
• On the mathematical modeling of inflammatory edema formation
• Chemotherapeutic Effects on Hematopoiesis: A Mathematical Model
• scientific article; zbMATH DE number 1303478
• A mathematical model for chemoimmunotherapy of chronic lymphocytic leukemia
• A mathematical model of chemotherapy with variable infusion

This page was built for publication: Fluid-retention side-effects of the chemotherapy-supportive treatment interleukin-11: mathematical modelling of putative underlying mechanisms

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q883746)