Optimal experimental designs for fMRI via circulant biased weighing designs
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Abstract: Functional magnetic resonance imaging (fMRI) technology is popularly used in many fields for studying how the brain reacts to mental stimuli. The identification of optimal fMRI experimental designs is crucial for rendering precise statistical inference on brain functions, but research on this topic is very lacking. We develop a general theory to guide the selection of fMRI designs for estimating a hemodynamic response function (HRF) that models the effect over time of the mental stimulus, and for studying the comparison of two HRFs. We provide a useful connection between fMRI designs and circulant biased weighing designs, establish the statistical optimality of some well-known fMRI designs and identify several new classes of fMRI designs. Construction methods of high-quality fMRI designs are also given.
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Cited in
(13)- Hypothesis testing, power and sample size determination for between group comparisons in fMRI experiments
- On optimal fMRI designs for correlated errors
- Optimal and efficient designs for fMRI experiments via two-level circulant almost orthogonal arrays
- A new type of experimental designs for event-related fMRI via Hadamard matrices
- Optimal design for event-related fMRI studies
- Optimization of blocked designs in fMRI studies
- Optimal and efficient designs for functional brain imaging experiments
- On the optimality of extended maximal length linear feedback shift register sequences
- Optimal design of fMRI experiments using circulant (almost-)orthogonal arrays
- Efficient experimental plans for second-order event-related functional magnetic resonance imaging
- Efficient Designs for Event-Related Functional Magnetic Resonance Imaging with Multiple Scanning Sessions
- An investigation of a quadratic design criterion for estimation of the hemodynamic response function
- Recent developments in D-optimal designs
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