Negative feedback contributes to the stochastic expression of the interferon- gene in virus-triggered type I interferon signaling pathways

DOI10.1016/J.MBS.2015.04.003MaRDI QIDQ894272zbMATH OpenOpenAlexWikidataFDO

Authors N. E. Zubov

Publication date 30 November 2015

Published in Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.mbs.2015.04.003

zbMATH Keywords

mathematical modelstochasticitybifurcation analysisfeedbackstype I IFN signaling pathways

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Bifurcation theory for ordinary differential equations (34C23) Feedback control (93B52)

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Cites work

• A methodology for performing global uncertainty and sensitivity analysis in systems biology
• An introduction to systems biology. Design principles of biological circuits.
• Complex dynamical analysis of a coupled network from innate immune responses
• Linear noise approximation for stochastic oscillations of intracellular calcium
• Mathematical modeling for intracellular transport and binding of HIV-1 gag proteins
• Modeling and Simulating Chemical Reactions
• Numerical methods for strong solutions of stochastic differential equations: an overview
• Optimal control strategy for abnormal innate immune response
• Simulating, Analyzing, and Animating Dynamical Systems

Cited in

(4)

• Robustness of the signal transduction system of the mammalian JAK/STAT pathway and dimerization steps
• Mechanistic modeling explains the dsRNA length-dependent activation of the RIG-I mediated immune response
• Several indicators of critical transitions for complex diseases based on stochastic analysis
• Mathematical modeling of the cGAS pathway reveals robustness of DNA sensing to TREX1 feedback

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Uses Software

• XPPAUT

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