Scaling limits of spatial compartment models for chemical reaction networks

DOI10.1214/14-AAP1070zbMATH Open1329.60341arXiv1302.0774OpenAlexW2131942680MaRDI QIDQ894804FDOQ894804

Authors: Peter Pfaffelhuber, Lea Popovic 

Publication date: 24 November 2015

Published in: The Annals of Applied Probability (Search for Journal in Brave)

Abstract: We study the effects of fast spatial movement of molecules on the dynamics of chemical species in a spatially heterogeneous chemical reaction network using a compartment model. The reaction networks we consider are either single- or multi-scale. When reaction dynamics is on a single-scale, fast spatial movement has a simple effect of averaging reactions over the distribution of all the species. When reaction dynamics is on multiple scales, we show that spatial movement of molecules has different effects depending on whether the movement of each type of species is faster or slower than the effective reaction dynamics on this molecular type. We obtain results for both when the system is without and with conserved quantities, which are linear combinations of species evolving only on the slower time scale.

Full work available at URL: https://arxiv.org/abs/1302.0774

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zbMATH Keywords

multiple time scalesscaling limitsstochastic averagingchemical reaction networkquasi-steady state assumption

Mathematics Subject Classification ID

Interacting random processes; statistical mechanics type models; percolation theory (60K35) Functional limit theorems; invariance principles (60F17) Continuous-time Markov processes on general state spaces (60J25) Continuous-time Markov processes on discrete state spaces (60J27) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Chemical kinetics in thermodynamics and heat transfer (80A30)

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Cited In (11)

• Stochastically modeled weakly reversible reaction networks with a single linkage class
• Reduction for Stochastic Biochemical Reaction Networks with Multiscale Conservations
• Fast reactions with non-interacting species in stochastic reaction networks
• Accuracy of Multiscale Reduction for Stochastic Reaction Systems
• A spatial measure-valued model for chemical reaction networks in heterogeneous systems
• On mean-field super-Brownian motions
• Discrepancies between extinction events and boundary equilibria in reaction networks
• A spatial measure-valued model for radiation-induced DNA damage kinetics and repair under protracted irradiation condition
• Uniform Approximation of Solutions by Elimination of Intermediate Species in Deterministic Reaction Networks
• Finite Time Distributions of Stochastically Modeled Chemical Systems with Absolute Concentration Robustness
• The fixation probability and time for a doubly beneficial mutant

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