Model for acid-mediated tumour invasion with chemotherapy intervention. II: Spatially heterogeneous populations
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Publication:899329
DOI10.1016/J.MBS.2015.09.007zbMATH Open1364.92018arXiv1412.0748OpenAlexW2963237898WikidataQ50794131 ScholiaQ50794131MaRDI QIDQ899329FDOQ899329
Marianito R. Rodrigo, Andrew B. Holder
Publication date: 28 December 2015
Published in: Mathematical Biosciences (Search for Journal in Brave)
Abstract: The acid-mediation hypothesis, that is, the hypothesis that acid produced by tumours, as a result of aerobic glycolysis, provides a mechanism for invasion, has so far been considered as a relatively closed system. The focus has mainly been on the dynamics of the tumour, normal-tissue, acid and possibly some other bodily components, without considering the effect of an external intervention such as a cytotoxic treatment. This article aims to examine the effect that a cytotoxic treatment has on a tumour growing under the acid-mediation hypothesis by using a simple set of ordinary differential equations that consider the interaction between normal-tissue, tumour-tissue, acid and chemotherapy drug.
Full work available at URL: https://arxiv.org/abs/1412.0748
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Cited In (5)
- Spatiotemporal dynamics of immunogenic tumors
- Travelling wave analysis of cellular invasion into surrounding tissues
- Propagation fronts in a simplified model of tumor growth with degenerate cross-dependent self-diffusivity
- A general reaction-diffusion model of acidity in cancer invasion
- EXISTENCE AND OPTIMAL CONTROL ANALYSIS OF ACID-MEDIATED TUMOR INVASION
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